Abstract

Primary CD30(Ki-1)-positive anaplastic large-cell lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30- positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study.

Original languageEnglish (US)
Pages (from-to)3860-3868
Number of pages9
JournalBlood
Volume87
Issue number9
StatePublished - May 1 1996

Fingerprint

Anaplastic Large-Cell Lymphoma
T-cells
Non-Hodgkin's Lymphoma
Bone
Cells
Registries
Lymphoma
Peripheral T-Cell Lymphoma
B-Cell Lymphoma
Bone Marrow Transplantation
Cytogenetics
Young Adult
T-Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Weisenburger, D. D., Gordon, B. G., Vose, J. M., Bast, M. A., Chan, W. C., Greiner, T. C., ... Sanger, W. G. (1996). Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma. Blood, 87(9), 3860-3868.

Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma. / Weisenburger, Dennis D.; Gordon, Bruce Geoffrey; Vose, Julie Marie; Bast, Martin A.; Chan, Wing C.; Greiner, Timothy Charles; Anderson, James R.; Sanger, Warren G.

In: Blood, Vol. 87, No. 9, 01.05.1996, p. 3860-3868.

Research output: Contribution to journalArticle

Weisenburger, DD, Gordon, BG, Vose, JM, Bast, MA, Chan, WC, Greiner, TC, Anderson, JR & Sanger, WG 1996, 'Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma', Blood, vol. 87, no. 9, pp. 3860-3868.
Weisenburger DD, Gordon BG, Vose JM, Bast MA, Chan WC, Greiner TC et al. Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma. Blood. 1996 May 1;87(9):3860-3868.
Weisenburger, Dennis D. ; Gordon, Bruce Geoffrey ; Vose, Julie Marie ; Bast, Martin A. ; Chan, Wing C. ; Greiner, Timothy Charles ; Anderson, James R. ; Sanger, Warren G. / Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma. In: Blood. 1996 ; Vol. 87, No. 9. pp. 3860-3868.
@article{624498c4dffe4f428db8327b188c1e73,
title = "Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma",
abstract = "Primary CD30(Ki-1)-positive anaplastic large-cell lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30- positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study.",
author = "Weisenburger, {Dennis D.} and Gordon, {Bruce Geoffrey} and Vose, {Julie Marie} and Bast, {Martin A.} and Chan, {Wing C.} and Greiner, {Timothy Charles} and Anderson, {James R.} and Sanger, {Warren G.}",
year = "1996",
month = "5",
day = "1",
language = "English (US)",
volume = "87",
pages = "3860--3868",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "9",

}

TY - JOUR

T1 - Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma

AU - Weisenburger, Dennis D.

AU - Gordon, Bruce Geoffrey

AU - Vose, Julie Marie

AU - Bast, Martin A.

AU - Chan, Wing C.

AU - Greiner, Timothy Charles

AU - Anderson, James R.

AU - Sanger, Warren G.

PY - 1996/5/1

Y1 - 1996/5/1

N2 - Primary CD30(Ki-1)-positive anaplastic large-cell lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30- positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study.

AB - Primary CD30(Ki-1)-positive anaplastic large-cell lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30- positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study.

UR - http://www.scopus.com/inward/record.url?scp=0029981836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029981836&partnerID=8YFLogxK

M3 - Article

VL - 87

SP - 3860

EP - 3868

JO - Blood

JF - Blood

SN - 0006-4971

IS - 9

ER -