Occupational and environmental risk factors for idiopathic pulmonary fibrosis: A multicenter case-control study

Kathy B. Baumgartner, Jonathan M. Samet, David B. Coultas, Christine A. Stidley, William C. Hunt, Thomas V. Colby, James A. Waldron, Robert Baughman, Gerald S. Davis, Joe G.N. Garcia, Gary W. Hunningshake, Michael C. Kallay, Talmadge E. King, Michael J. Krowka, Stephen I. Rennard, Jay H. Ryu, Charles B. Sherman, Lewis J. Smith, Galen Toews, Richard H. Winterbauer

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Occupational exposures were investigated in a multicenter case-control study of clinically and histologically diagnosed idiopathic pulmonary fibrosis (IPF), a chronic diffuse interstitial lung disease of unknown etiology. Results are based on 248 cases, aged 20-75 years, diagnosed at 16 referral centers between January 1989 and July 1993. There were 491 controls ascertained by random digit dialing and matched to cases on sex, age, and geographic region. Data were collected using a standard telephone questionnaire. Occupational factors were based on a detailed history of jobs lasting 6 months or more and job activity, hobby, and specific substance checklists. Several occupational factors, adjusted for age and smoking in conditional multivariate logistic regression analyses, were significantly associated with IPF: farming (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5); livestock (OR = 2.7, 95% CI: 1.3, 5.5); hairdressing (OR = 4.4, 95% CI: 1.2, 16.3); metal dust (OR = 2.0, 95% CI: 1.0, 4.0); raising birds (OR = 4.7, 95% CI: 1.6, 14.1); stone cutting/polishing (OR = 3.9, 95% CI: 1.2, 12.7); and vegetable dust/animal dust (OR = 4.7, 95% CI: 2.1, 10.4). Interaction was detected between smoking and exposure to livestock (p = 0.06) and farming (p = 0.08). Results confirm previous studies showing increased risk associated with dusty environments.

Original languageEnglish (US)
Pages (from-to)307-315
Number of pages9
JournalAmerican Journal of Epidemiology
Volume152
Issue number4
DOIs
StatePublished - Aug 15 2000

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Idiopathic Pulmonary Fibrosis
Case-Control Studies
Odds Ratio
Confidence Intervals
Dust
Livestock
Agriculture
Smoking
Hobbies
Age Factors
Interstitial Lung Diseases
Occupational Exposure
Checklist
Telephone
Vegetables
Birds
Referral and Consultation
Logistic Models
Metals
Regression Analysis

Keywords

  • Case-control studies
  • Environmental exposure
  • Occupational exposure
  • Pulmonary fibrosis
  • Risk factors

ASJC Scopus subject areas

  • Epidemiology

Cite this

Baumgartner, K. B., Samet, J. M., Coultas, D. B., Stidley, C. A., Hunt, W. C., Colby, T. V., ... Winterbauer, R. H. (2000). Occupational and environmental risk factors for idiopathic pulmonary fibrosis: A multicenter case-control study. American Journal of Epidemiology, 152(4), 307-315. https://doi.org/10.1093/aje/152.4.307

Occupational and environmental risk factors for idiopathic pulmonary fibrosis : A multicenter case-control study. / Baumgartner, Kathy B.; Samet, Jonathan M.; Coultas, David B.; Stidley, Christine A.; Hunt, William C.; Colby, Thomas V.; Waldron, James A.; Baughman, Robert; Davis, Gerald S.; Garcia, Joe G.N.; Hunningshake, Gary W.; Kallay, Michael C.; King, Talmadge E.; Krowka, Michael J.; Rennard, Stephen I.; Ryu, Jay H.; Sherman, Charles B.; Smith, Lewis J.; Toews, Galen; Winterbauer, Richard H.

In: American Journal of Epidemiology, Vol. 152, No. 4, 15.08.2000, p. 307-315.

Research output: Contribution to journalArticle

Baumgartner, KB, Samet, JM, Coultas, DB, Stidley, CA, Hunt, WC, Colby, TV, Waldron, JA, Baughman, R, Davis, GS, Garcia, JGN, Hunningshake, GW, Kallay, MC, King, TE, Krowka, MJ, Rennard, SI, Ryu, JH, Sherman, CB, Smith, LJ, Toews, G & Winterbauer, RH 2000, 'Occupational and environmental risk factors for idiopathic pulmonary fibrosis: A multicenter case-control study', American Journal of Epidemiology, vol. 152, no. 4, pp. 307-315. https://doi.org/10.1093/aje/152.4.307
Baumgartner, Kathy B. ; Samet, Jonathan M. ; Coultas, David B. ; Stidley, Christine A. ; Hunt, William C. ; Colby, Thomas V. ; Waldron, James A. ; Baughman, Robert ; Davis, Gerald S. ; Garcia, Joe G.N. ; Hunningshake, Gary W. ; Kallay, Michael C. ; King, Talmadge E. ; Krowka, Michael J. ; Rennard, Stephen I. ; Ryu, Jay H. ; Sherman, Charles B. ; Smith, Lewis J. ; Toews, Galen ; Winterbauer, Richard H. / Occupational and environmental risk factors for idiopathic pulmonary fibrosis : A multicenter case-control study. In: American Journal of Epidemiology. 2000 ; Vol. 152, No. 4. pp. 307-315.
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