Observed and expected incidence of cervical cancer in Lusaka and the southern and western provinces of Zambia, 2007 to 2012

Mulele Kalima, Kennedy Lishimpi, Jane L Meza, Shinobu Watanabe-Galloway, Susan C. Msadabwe, Catherine K. Mwaba, Aaron L. Shibemba, Lewis Banda, Charles Wood, Robert M. Chamberlain, Amr S. Soliman

Research output: Contribution to journalArticle

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Abstract

Objectives: Cervical cancer is increasing but underestimated in developing countries. We calculated the observed and expected incidence of cervical cancer in Lusaka and Southern and Western provinces of Zambia. Methods/Materials: Data for 2007 to 2012were obtained for the 3 provinces. Data included age, residence, year of diagnosis, marital status, occupation, human immunodeficiency virus (HIV), stage, radiotherapy, and chemotherapy. Expected incidence in Southern and Western provinceswas calculated based on observed incidence for Lusaka province, adjusting for HIV. Results: Crude and age-standardized incidence rates (ASRs) in Lusaka were 2 to 4 times higher than incidence in the other 2 provinces. Lusaka had a rate of 54.1 per 105 and ASR of 82.1 per 105 in the age group of 15 to 49 years. The Southern province had a rate of 17.1 per 105 and ASR of 25.5 per 105; the Western province had a rate of 12.3 per 105 and ASR rate of 17.2 per 105. The observed cervical cancer incidence rates in the Southern and Western provinces were lower than the rate in Lusaka, possibly because of the uncertainty of underreporting/underdiagnosis or actual lower risk for reasons yet unclear. The HIV seroprevalence rates in patients from the 3 provinces were 46% to 93% higher than seroprevalence in the respective general populations. Conclusions: Cervical cancer is significantly underestimated in Zambia, and HIV has a significant role in pathogenesis. Future studies should establish methods for case ascertainment and better utilization of hospital- And population-based registries in Zambia and other similar developing countries.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalInternational Journal of Gynecological Cancer
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2015

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Zambia
Uterine Cervical Neoplasms
Incidence
HIV
Seroepidemiologic Studies
Developing Countries
Marital Status
Occupations
Population
Uncertainty
Registries
Radiotherapy
Age Groups
Drug Therapy

Keywords

  • Cervical cancer
  • Developing countries
  • Incidence
  • Zambia

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Observed and expected incidence of cervical cancer in Lusaka and the southern and western provinces of Zambia, 2007 to 2012. / Kalima, Mulele; Lishimpi, Kennedy; Meza, Jane L; Watanabe-Galloway, Shinobu; Msadabwe, Susan C.; Mwaba, Catherine K.; Shibemba, Aaron L.; Banda, Lewis; Wood, Charles; Chamberlain, Robert M.; Soliman, Amr S.

In: International Journal of Gynecological Cancer, Vol. 25, No. 1, 01.01.2015, p. 98-105.

Research output: Contribution to journalArticle

Kalima, Mulele ; Lishimpi, Kennedy ; Meza, Jane L ; Watanabe-Galloway, Shinobu ; Msadabwe, Susan C. ; Mwaba, Catherine K. ; Shibemba, Aaron L. ; Banda, Lewis ; Wood, Charles ; Chamberlain, Robert M. ; Soliman, Amr S. / Observed and expected incidence of cervical cancer in Lusaka and the southern and western provinces of Zambia, 2007 to 2012. In: International Journal of Gynecological Cancer. 2015 ; Vol. 25, No. 1. pp. 98-105.
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abstract = "Objectives: Cervical cancer is increasing but underestimated in developing countries. We calculated the observed and expected incidence of cervical cancer in Lusaka and Southern and Western provinces of Zambia. Methods/Materials: Data for 2007 to 2012were obtained for the 3 provinces. Data included age, residence, year of diagnosis, marital status, occupation, human immunodeficiency virus (HIV), stage, radiotherapy, and chemotherapy. Expected incidence in Southern and Western provinceswas calculated based on observed incidence for Lusaka province, adjusting for HIV. Results: Crude and age-standardized incidence rates (ASRs) in Lusaka were 2 to 4 times higher than incidence in the other 2 provinces. Lusaka had a rate of 54.1 per 105 and ASR of 82.1 per 105 in the age group of 15 to 49 years. The Southern province had a rate of 17.1 per 105 and ASR of 25.5 per 105; the Western province had a rate of 12.3 per 105 and ASR rate of 17.2 per 105. The observed cervical cancer incidence rates in the Southern and Western provinces were lower than the rate in Lusaka, possibly because of the uncertainty of underreporting/underdiagnosis or actual lower risk for reasons yet unclear. The HIV seroprevalence rates in patients from the 3 provinces were 46{\%} to 93{\%} higher than seroprevalence in the respective general populations. Conclusions: Cervical cancer is significantly underestimated in Zambia, and HIV has a significant role in pathogenesis. Future studies should establish methods for case ascertainment and better utilization of hospital- And population-based registries in Zambia and other similar developing countries.",
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T1 - Observed and expected incidence of cervical cancer in Lusaka and the southern and western provinces of Zambia, 2007 to 2012

AU - Kalima, Mulele

AU - Lishimpi, Kennedy

AU - Meza, Jane L

AU - Watanabe-Galloway, Shinobu

AU - Msadabwe, Susan C.

AU - Mwaba, Catherine K.

AU - Shibemba, Aaron L.

AU - Banda, Lewis

AU - Wood, Charles

AU - Chamberlain, Robert M.

AU - Soliman, Amr S.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objectives: Cervical cancer is increasing but underestimated in developing countries. We calculated the observed and expected incidence of cervical cancer in Lusaka and Southern and Western provinces of Zambia. Methods/Materials: Data for 2007 to 2012were obtained for the 3 provinces. Data included age, residence, year of diagnosis, marital status, occupation, human immunodeficiency virus (HIV), stage, radiotherapy, and chemotherapy. Expected incidence in Southern and Western provinceswas calculated based on observed incidence for Lusaka province, adjusting for HIV. Results: Crude and age-standardized incidence rates (ASRs) in Lusaka were 2 to 4 times higher than incidence in the other 2 provinces. Lusaka had a rate of 54.1 per 105 and ASR of 82.1 per 105 in the age group of 15 to 49 years. The Southern province had a rate of 17.1 per 105 and ASR of 25.5 per 105; the Western province had a rate of 12.3 per 105 and ASR rate of 17.2 per 105. The observed cervical cancer incidence rates in the Southern and Western provinces were lower than the rate in Lusaka, possibly because of the uncertainty of underreporting/underdiagnosis or actual lower risk for reasons yet unclear. The HIV seroprevalence rates in patients from the 3 provinces were 46% to 93% higher than seroprevalence in the respective general populations. Conclusions: Cervical cancer is significantly underestimated in Zambia, and HIV has a significant role in pathogenesis. Future studies should establish methods for case ascertainment and better utilization of hospital- And population-based registries in Zambia and other similar developing countries.

AB - Objectives: Cervical cancer is increasing but underestimated in developing countries. We calculated the observed and expected incidence of cervical cancer in Lusaka and Southern and Western provinces of Zambia. Methods/Materials: Data for 2007 to 2012were obtained for the 3 provinces. Data included age, residence, year of diagnosis, marital status, occupation, human immunodeficiency virus (HIV), stage, radiotherapy, and chemotherapy. Expected incidence in Southern and Western provinceswas calculated based on observed incidence for Lusaka province, adjusting for HIV. Results: Crude and age-standardized incidence rates (ASRs) in Lusaka were 2 to 4 times higher than incidence in the other 2 provinces. Lusaka had a rate of 54.1 per 105 and ASR of 82.1 per 105 in the age group of 15 to 49 years. The Southern province had a rate of 17.1 per 105 and ASR of 25.5 per 105; the Western province had a rate of 12.3 per 105 and ASR rate of 17.2 per 105. The observed cervical cancer incidence rates in the Southern and Western provinces were lower than the rate in Lusaka, possibly because of the uncertainty of underreporting/underdiagnosis or actual lower risk for reasons yet unclear. The HIV seroprevalence rates in patients from the 3 provinces were 46% to 93% higher than seroprevalence in the respective general populations. Conclusions: Cervical cancer is significantly underestimated in Zambia, and HIV has a significant role in pathogenesis. Future studies should establish methods for case ascertainment and better utilization of hospital- And population-based registries in Zambia and other similar developing countries.

KW - Cervical cancer

KW - Developing countries

KW - Incidence

KW - Zambia

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