O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The role of individual glucose metabolic pathways in innate immunity remains largely unknown. Li et al. demonstrate that attenuated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling enhances TLR-induced innate immune response and necroptosis. Mechanistically, O-GlcNAcylation of the kinase RIPK3 blocks RHIM-domain-mediated protein interaction and downstream signaling activation.

Original languageEnglish (US)
Pages (from-to)576-590.e6
JournalImmunity
Volume50
Issue number3
DOIs
StatePublished - Mar 19 2019

Fingerprint

Receptor-Interacting Protein Serine-Threonine Kinases
Innate Immunity
Protein Interaction Domains and Motifs
Inflammation
Acetylglucosamine
Metabolic Networks and Pathways
Phosphotransferases
Glucose
O-GlcNAc transferase

Keywords

  • HBP
  • O-GlcNAc
  • OGT
  • RIPK3
  • inflammation
  • necroptosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. / Li, Xinghui; Gong, Wei; Wang, Hao; Li, Tianliang; Attri, Kuldeep S.; Lewis, Robert E.; Kalil, Andre C.; Bhinderwala, Fatema; Powers, Robert; Yin, Guowei; Herring, Laura E.; Asara, John M.; Lei, Yu L.; Yang, Xiaoyong; Rodriguez, Diego A.; Yang, Mao; Green, Douglas R.; Singh, Pankaj K.; Wen, Haitao.

In: Immunity, Vol. 50, No. 3, 19.03.2019, p. 576-590.e6.

Research output: Contribution to journalArticle

Li, X, Gong, W, Wang, H, Li, T, Attri, KS, Lewis, RE, Kalil, AC, Bhinderwala, F, Powers, R, Yin, G, Herring, LE, Asara, JM, Lei, YL, Yang, X, Rodriguez, DA, Yang, M, Green, DR, Singh, PK & Wen, H 2019, 'O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3', Immunity, vol. 50, no. 3, pp. 576-590.e6. https://doi.org/10.1016/j.immuni.2019.01.007
Li, Xinghui ; Gong, Wei ; Wang, Hao ; Li, Tianliang ; Attri, Kuldeep S. ; Lewis, Robert E. ; Kalil, Andre C. ; Bhinderwala, Fatema ; Powers, Robert ; Yin, Guowei ; Herring, Laura E. ; Asara, John M. ; Lei, Yu L. ; Yang, Xiaoyong ; Rodriguez, Diego A. ; Yang, Mao ; Green, Douglas R. ; Singh, Pankaj K. ; Wen, Haitao. / O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. In: Immunity. 2019 ; Vol. 50, No. 3. pp. 576-590.e6.
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