Nucleotide sequence of the rat Bmyc gene

C. Asker, M. Steinitz, K. Andersson, Janos Sumegi, G. Klein, S. Ingvarsson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We have cloned and sequenced the rat Bmyc gene. The rat Bmyc gene contains sequences related to the central part of c-myc, namely the first intron, the second exon, and the noncoding part of the third exon. The homology drops in the 3' part of the c-myc second exon, but continues in the noncoding part of the third exon. We have sequenced the total predicted coding region of the Bmyc. The longest open reading frame in Bmyc suggests a protein of 178 amino acids, which is only 41% of the c-myc protein size. To confirm the putative open reading frame, we have produced a trpE-Bmyc protein that is detected with a pan-myc antibody. We discuss these findings in the context of potential functional domains and the possibility of overlapping and distinct activities of myc-family proteins.

Original languageEnglish (US)
Pages (from-to)1523-1527
Number of pages5
JournalOncogene
Volume4
Issue number12
StatePublished - Dec 22 1989

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Exons
Open Reading Frames
Genes
Proto-Oncogene Proteins c-myc
Proteins
Introns
Amino Acids
Antibodies

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Asker, C., Steinitz, M., Andersson, K., Sumegi, J., Klein, G., & Ingvarsson, S. (1989). Nucleotide sequence of the rat Bmyc gene. Oncogene, 4(12), 1523-1527.

Nucleotide sequence of the rat Bmyc gene. / Asker, C.; Steinitz, M.; Andersson, K.; Sumegi, Janos; Klein, G.; Ingvarsson, S.

In: Oncogene, Vol. 4, No. 12, 22.12.1989, p. 1523-1527.

Research output: Contribution to journalArticle

Asker, C, Steinitz, M, Andersson, K, Sumegi, J, Klein, G & Ingvarsson, S 1989, 'Nucleotide sequence of the rat Bmyc gene', Oncogene, vol. 4, no. 12, pp. 1523-1527.
Asker C, Steinitz M, Andersson K, Sumegi J, Klein G, Ingvarsson S. Nucleotide sequence of the rat Bmyc gene. Oncogene. 1989 Dec 22;4(12):1523-1527.
Asker, C. ; Steinitz, M. ; Andersson, K. ; Sumegi, Janos ; Klein, G. ; Ingvarsson, S. / Nucleotide sequence of the rat Bmyc gene. In: Oncogene. 1989 ; Vol. 4, No. 12. pp. 1523-1527.
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