Nucleotide sequence of the 5′-flanking region of the mouse κ-FGF oncogene exhibits an alternating purine

pyrimidine motif with the potential to form Z-DNA

Jay Tiesman, A Angie Rizzino

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The nucleotide sequence of the 5′-flanking region of the mouse κ-FGF oncogene has been determined. This sequence extends 2.1 kb upstream from the transcriptional start point (tsp) and includes two Sp1 and two AP-2 consensus binding sequences immediately 5′ of the TATA box. In addition, the sequence contains an alternating purine: pyrimidine motif that lies approx. 1 kb upstream from the tsp.

Original languageEnglish (US)
Pages (from-to)311-312
Number of pages2
JournalGene
Volume96
Issue number2
DOIs
StatePublished - Dec 15 1990

Fingerprint

Z-Form DNA
TATA Box
5' Flanking Region
Consensus Sequence
Oncogenes
pyrimidine
purine

Keywords

  • Recombinant DNA
  • consensus binding sequence
  • transcription factors AP-2 andSp1

ASJC Scopus subject areas

  • Genetics

Cite this

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abstract = "The nucleotide sequence of the 5′-flanking region of the mouse κ-FGF oncogene has been determined. This sequence extends 2.1 kb upstream from the transcriptional start point (tsp) and includes two Sp1 and two AP-2 consensus binding sequences immediately 5′ of the TATA box. In addition, the sequence contains an alternating purine: pyrimidine motif that lies approx. 1 kb upstream from the tsp.",
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AU - Rizzino, A Angie

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N2 - The nucleotide sequence of the 5′-flanking region of the mouse κ-FGF oncogene has been determined. This sequence extends 2.1 kb upstream from the transcriptional start point (tsp) and includes two Sp1 and two AP-2 consensus binding sequences immediately 5′ of the TATA box. In addition, the sequence contains an alternating purine: pyrimidine motif that lies approx. 1 kb upstream from the tsp.

AB - The nucleotide sequence of the 5′-flanking region of the mouse κ-FGF oncogene has been determined. This sequence extends 2.1 kb upstream from the transcriptional start point (tsp) and includes two Sp1 and two AP-2 consensus binding sequences immediately 5′ of the TATA box. In addition, the sequence contains an alternating purine: pyrimidine motif that lies approx. 1 kb upstream from the tsp.

KW - Recombinant DNA

KW - consensus binding sequence

KW - transcription factors AP-2 andSp1

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