Nucleoside and nucleobase analog mutagens

Kazuo Negishi, Tadayashi Bessho, Hikoya Hayatsu

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.

Original languageEnglish (US)
Pages (from-to)227-238
Number of pages12
JournalMutation Research/Reviews in Genetic Toxicology
Volume318
Issue number3
DOIs
StatePublished - Dec 1994

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ASJC Scopus subject areas

  • Toxicology
  • Genetics

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