Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated Protein quality control in cardiomyocytes

Taixing Cui, Yimu Lai, Joseph S. Janicki, Xuejun Wang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Protein quality control (PQC) acts to minimize the level and toxicity of malfolded proteins in the cell. It is performed by an elaborate network of molecular chaperones and targeted protein degradation pathways. PQC monitors and maintains protein homeostasis or proteostasis in the cells. Whilst chaperones may actively promote refolding of malfolded proteins, the malfolded proteins which cannot be correctly refolded are degraded by the ubiquitin proteasome system (UPS) and the autophagic-lysosome pathway (ALP). The UPS degrades individual misfolded protein molecules, whereas the ALP removes large and less soluble protein aggregates and organelles. Emerging evidence indicates that dysregulated and inadequate PQC play an important role in the pathogenesis of not only classic conformational disease but more common forms of cardiac pathology such as cardiac pathological hypertrophy and heart failure. Nuclear factor erythroid 2-related factor 2 (Nrf2), a master transcription factor of cellular defense, appears to regulate the USP and the ALP by directly controlling the expression of UPS- and ALP-related genes. This article highlights an emerging role of Nrf2 in the regulation of intracellular PQC as well as its potential involvement in cardiac pathology.

Original languageEnglish (US)
Pages (from-to)192-202
Number of pages11
JournalFrontiers in Bioscience - Landmark
Volume21
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Cardiac Myocytes
Quality Control
Quality control
Lysosomes
Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Pathology
Protein Refolding
Molecular Chaperones
Cardiomegaly
Organelles
Proteolysis
Homeostasis
Transcription Factors
Heart Failure
Toxicity
Genes
Degradation
Molecules

Keywords

  • Autophagy
  • Nuclear factor erythroid-2 related factor 2
  • Proteasome
  • Protein quality control

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated Protein quality control in cardiomyocytes. / Cui, Taixing; Lai, Yimu; Janicki, Joseph S.; Wang, Xuejun.

In: Frontiers in Bioscience - Landmark, Vol. 21, No. 1, 01.01.2016, p. 192-202.

Research output: Contribution to journalArticle

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