N5-Phosphonoacetyl-l-ornithine (PALO)

A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae

Brad Johnson, Rachel Steadman, Krista D. Patefield, Jeffrey J. Bunker, Audrey L Atkin, Patrick H Dussault

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N5-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.

Original languageEnglish (US)
Pages (from-to)2351-2353
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number8
DOIs
StatePublished - Apr 15 2011

Fingerprint

Ornithine
Yeast
Saccharomyces cerevisiae
Genes
Amino Acids
Ornithine Carbamoyltransferase
Metabolism
Arginine
Gene Expression
Growth

Keywords

  • Arginine biosynthesis
  • Ornithine transcarbamylase
  • PALO
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

N5-Phosphonoacetyl-l-ornithine (PALO) : A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae. / Johnson, Brad; Steadman, Rachel; Patefield, Krista D.; Bunker, Jeffrey J.; Atkin, Audrey L; Dussault, Patrick H.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 8, 15.04.2011, p. 2351-2353.

Research output: Contribution to journalArticle

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AU - Dussault, Patrick H

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