Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism

Janos Zempleni, Dandan Liu, Daniel Teixeira Camara, Elizabeth L. Cordonier

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The role of holocarboxylase synthetase (HLCS) in catalyzing the covalent binding of biotin to the five biotin-dependent carboxylases in humans is well established, as are the essential roles of these carboxylases in the metabolism of fatty acids, the catabolism of leucine, and gluconeogenesis. This review examines recent discoveries regarding the roles of HLCS in assembling a multiprotein gene repression complex in chromatin. In addition, emerging evidence suggests that the number of biotinylated proteins is far larger than previously assumed and includes members of the heat-shock superfamily of proteins and proteins coded by the ENO1 gene. Evidence is presented linking biotinylation of heat-shock proteins HSP60 and HSP72 with redox biology and immune function, respectively, and biotinylation of the two ENO1 gene products MBP-1 and ENO1 with tumor suppression and glycolysis, respectively.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalNutrition Reviews
Volume72
Issue number6
DOIs
StatePublished - Jan 1 2014

Fingerprint

Biotinylation
biotin carboxylase
HSP72 Heat-Shock Proteins
Genes
Gluconeogenesis
Glycolysis
Biotin
Heat-Shock Proteins
Leucine
Chromatin
Oxidation-Reduction
Proteins
Fatty Acids
holocarboxylase synthetases
Neoplasms

Keywords

  • Chromatin
  • Epigenetics
  • Gene regulation
  • Holocarboxylase synthetase
  • Metabolism

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism. / Zempleni, Janos; Liu, Dandan; Teixeira Camara, Daniel; Cordonier, Elizabeth L.

In: Nutrition Reviews, Vol. 72, No. 6, 01.01.2014, p. 369-376.

Research output: Contribution to journalArticle

Zempleni, Janos ; Liu, Dandan ; Teixeira Camara, Daniel ; Cordonier, Elizabeth L. / Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism. In: Nutrition Reviews. 2014 ; Vol. 72, No. 6. pp. 369-376.
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