Novel insights into RV adaptation and function in hypoplastic left heart syndrome between the first 2 stages of surgical palliation

Nee Scze Khoo, Jeffrey F. Smallhorn, Sachie Kaneko, Kimberly Myers, Shelby Kutty, Edythe B. Tham

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Abstract

Objectives: This study sought to examine the changes in ventricular function of hypoplastic left heart syndrome (HLHS) between the first 2 stages of surgical palliation. Background: The mortality risk between first and second stages of surgical palliation in HLHS remains high. Right ventricular (RV) dysfunction predicts mortality. Postulated mechanisms include a maladaptive contraction pattern, myocardial ischemia, or contraction asynchrony. Speckle tracking imaging allows accurate measurement of myocardial deformation without geometric assumptions. Methods: Prospective echocardiography pre-Norwood and pre-bidirectional cavopulmonary anastomosis (BCPA) examinations were performed in 20 HLHS patients, with comparisons made between stages. Measurements of ventricular function included: longitudinal/circumferential strain ratio, reflecting changes in contraction pattern; post-systolic strain index, a potential marker of myocardial ischemia; and mechanical dyssynchrony index. Relationships between echocardiographic variables and magnetic resonance imaging RV parameters before BCPA were examined. Results: Before BCPA, myocardial contractility estimated by isovolumic acceleration and strain rate was reduced, paralleled by an increased in post-systolic strain index (p < 0.01). Right ventricular longitudinal/circumferential strain ratio decreased, becoming similar to a left ventriclelike contraction pattern, and this correlated with decreased mechanical dyssynchrony index (r = 0.65, p < 0.01), magnetic resonance imaging RV end-diastolic volume (r = 0.65, p < 0.05) and mass (r = 0.71, p < 0.01). Ventricular strain (r = 0.72, p < 0.01), strain rate (r = 0.85, p < 0.001), and mechanical dyssynchrony index (r = 0.73, p < 0.01) correlated linearly with magnetic resonance imagingderived RV ejection fraction. Conclusions: Reduced RV contractility occurred before BCPA. RV with a left ventriclelike contraction pattern was associated with improved contraction synchrony as well as a reduction in RV size and mass in HLHS. The finding of increased post-systolic strain index before BCPA is novel and its potential link with myocardial ischemia warrants further investigation. RV strain, strain rate, and contraction synchrony measured by speckle tracking imaging correlated closely with ventricular function and might be useful for monitoring ventricular function in HLHS.

Original languageEnglish (US)
Pages (from-to)128-137
Number of pages10
JournalJACC: Cardiovascular Imaging
Volume4
Issue number2
DOIs
StatePublished - Feb 1 2011

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Right Heart Bypass
Hypoplastic Left Heart Syndrome
Right Ventricular Function
Ventricular Function
Myocardial Ischemia
Stroke Volume
Magnetic Resonance Imaging
Right Ventricular Dysfunction
Myocardial Contraction
Mortality
Echocardiography
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Novel insights into RV adaptation and function in hypoplastic left heart syndrome between the first 2 stages of surgical palliation. / Khoo, Nee Scze; Smallhorn, Jeffrey F.; Kaneko, Sachie; Myers, Kimberly; Kutty, Shelby; Tham, Edythe B.

In: JACC: Cardiovascular Imaging, Vol. 4, No. 2, 01.02.2011, p. 128-137.

Research output: Contribution to journalArticle

Khoo, Nee Scze ; Smallhorn, Jeffrey F. ; Kaneko, Sachie ; Myers, Kimberly ; Kutty, Shelby ; Tham, Edythe B. / Novel insights into RV adaptation and function in hypoplastic left heart syndrome between the first 2 stages of surgical palliation. In: JACC: Cardiovascular Imaging. 2011 ; Vol. 4, No. 2. pp. 128-137.
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AU - Smallhorn, Jeffrey F.

AU - Kaneko, Sachie

AU - Myers, Kimberly

AU - Kutty, Shelby

AU - Tham, Edythe B.

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N2 - Objectives: This study sought to examine the changes in ventricular function of hypoplastic left heart syndrome (HLHS) between the first 2 stages of surgical palliation. Background: The mortality risk between first and second stages of surgical palliation in HLHS remains high. Right ventricular (RV) dysfunction predicts mortality. Postulated mechanisms include a maladaptive contraction pattern, myocardial ischemia, or contraction asynchrony. Speckle tracking imaging allows accurate measurement of myocardial deformation without geometric assumptions. Methods: Prospective echocardiography pre-Norwood and pre-bidirectional cavopulmonary anastomosis (BCPA) examinations were performed in 20 HLHS patients, with comparisons made between stages. Measurements of ventricular function included: longitudinal/circumferential strain ratio, reflecting changes in contraction pattern; post-systolic strain index, a potential marker of myocardial ischemia; and mechanical dyssynchrony index. Relationships between echocardiographic variables and magnetic resonance imaging RV parameters before BCPA were examined. Results: Before BCPA, myocardial contractility estimated by isovolumic acceleration and strain rate was reduced, paralleled by an increased in post-systolic strain index (p < 0.01). Right ventricular longitudinal/circumferential strain ratio decreased, becoming similar to a left ventriclelike contraction pattern, and this correlated with decreased mechanical dyssynchrony index (r = 0.65, p < 0.01), magnetic resonance imaging RV end-diastolic volume (r = 0.65, p < 0.05) and mass (r = 0.71, p < 0.01). Ventricular strain (r = 0.72, p < 0.01), strain rate (r = 0.85, p < 0.001), and mechanical dyssynchrony index (r = 0.73, p < 0.01) correlated linearly with magnetic resonance imagingderived RV ejection fraction. Conclusions: Reduced RV contractility occurred before BCPA. RV with a left ventriclelike contraction pattern was associated with improved contraction synchrony as well as a reduction in RV size and mass in HLHS. The finding of increased post-systolic strain index before BCPA is novel and its potential link with myocardial ischemia warrants further investigation. RV strain, strain rate, and contraction synchrony measured by speckle tracking imaging correlated closely with ventricular function and might be useful for monitoring ventricular function in HLHS.

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