Novel drug delivery systems based on the complexes of block ionomers and surfactants of opposite charge

Tatiana K Bronich, Andrew Nehls, Adi Eisenberg, Victor A. Kabanov, Alexander V. Kabanov

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

In this paper we have evaluated a novel family of polymer-surfactant complexes formed between block ionomers and oppositely charged surfactants. Complexes between cationic copolymer poly(ethylene oxide)-g-polyethyleneimine (PEO-g-PEI) and sodium salt of oleic acid, natural nontoxic surfactant, are prepared and characterized. These systems self-assemble in aqueous solutions into particles with average size of 50-60 nm, which can solubilize hydrophobic dyes (Yellow OB) and drug molecules (paclitaxel). The use of the biologically active surfactants as components of block ionomer complexes is demonstrated for the complexes from PEO-g-PEI and all-trans-retinoic acid. Binding of relatively soluble drugs with block ionomers is illustrated using PEO-b-poly(sodium methacrylate) and doxorubicin. Overall these studies suggest that block ionomer complexes can be used to prepare a variety of soluble and stable formulations of biologically active compounds, and have potential application as drug delivery systems.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume16
Issue number1-4
DOIs
StatePublished - Nov 1 1999

Fingerprint

Ionomers
Drug Delivery Systems
Surface-Active Agents
delivery
drugs
Surface active agents
Polyethylene oxides
surfactants
Polyethyleneimine
Ethylene Oxide
ethylene oxide
Sodium
sodium
oleic acid
Oleic acid
Oleic Acid
Paclitaxel
Tretinoin
Pharmaceutical Preparations
Doxorubicin

Keywords

  • All-trans- retinoic acid
  • Block copolymers
  • Doxorubicin
  • Oleic acid
  • Paclitaxel
  • Polymer-surfactant complexes

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Novel drug delivery systems based on the complexes of block ionomers and surfactants of opposite charge. / Bronich, Tatiana K; Nehls, Andrew; Eisenberg, Adi; Kabanov, Victor A.; Kabanov, Alexander V.

In: Colloids and Surfaces B: Biointerfaces, Vol. 16, No. 1-4, 01.11.1999, p. 243-251.

Research output: Contribution to journalArticle

Bronich, Tatiana K ; Nehls, Andrew ; Eisenberg, Adi ; Kabanov, Victor A. ; Kabanov, Alexander V. / Novel drug delivery systems based on the complexes of block ionomers and surfactants of opposite charge. In: Colloids and Surfaces B: Biointerfaces. 1999 ; Vol. 16, No. 1-4. pp. 243-251.
@article{2c53bf38f0604e12a89d649d88e553aa,
title = "Novel drug delivery systems based on the complexes of block ionomers and surfactants of opposite charge",
abstract = "In this paper we have evaluated a novel family of polymer-surfactant complexes formed between block ionomers and oppositely charged surfactants. Complexes between cationic copolymer poly(ethylene oxide)-g-polyethyleneimine (PEO-g-PEI) and sodium salt of oleic acid, natural nontoxic surfactant, are prepared and characterized. These systems self-assemble in aqueous solutions into particles with average size of 50-60 nm, which can solubilize hydrophobic dyes (Yellow OB) and drug molecules (paclitaxel). The use of the biologically active surfactants as components of block ionomer complexes is demonstrated for the complexes from PEO-g-PEI and all-trans-retinoic acid. Binding of relatively soluble drugs with block ionomers is illustrated using PEO-b-poly(sodium methacrylate) and doxorubicin. Overall these studies suggest that block ionomer complexes can be used to prepare a variety of soluble and stable formulations of biologically active compounds, and have potential application as drug delivery systems.",
keywords = "All-trans- retinoic acid, Block copolymers, Doxorubicin, Oleic acid, Paclitaxel, Polymer-surfactant complexes",
author = "Bronich, {Tatiana K} and Andrew Nehls and Adi Eisenberg and Kabanov, {Victor A.} and Kabanov, {Alexander V.}",
year = "1999",
month = "11",
day = "1",
doi = "10.1016/S0927-7765(99)00075-2",
language = "English (US)",
volume = "16",
pages = "243--251",
journal = "Colloids and Surfaces B: Biointerfaces",
issn = "0927-7765",
publisher = "Elsevier",
number = "1-4",

}

TY - JOUR

T1 - Novel drug delivery systems based on the complexes of block ionomers and surfactants of opposite charge

AU - Bronich, Tatiana K

AU - Nehls, Andrew

AU - Eisenberg, Adi

AU - Kabanov, Victor A.

AU - Kabanov, Alexander V.

PY - 1999/11/1

Y1 - 1999/11/1

N2 - In this paper we have evaluated a novel family of polymer-surfactant complexes formed between block ionomers and oppositely charged surfactants. Complexes between cationic copolymer poly(ethylene oxide)-g-polyethyleneimine (PEO-g-PEI) and sodium salt of oleic acid, natural nontoxic surfactant, are prepared and characterized. These systems self-assemble in aqueous solutions into particles with average size of 50-60 nm, which can solubilize hydrophobic dyes (Yellow OB) and drug molecules (paclitaxel). The use of the biologically active surfactants as components of block ionomer complexes is demonstrated for the complexes from PEO-g-PEI and all-trans-retinoic acid. Binding of relatively soluble drugs with block ionomers is illustrated using PEO-b-poly(sodium methacrylate) and doxorubicin. Overall these studies suggest that block ionomer complexes can be used to prepare a variety of soluble and stable formulations of biologically active compounds, and have potential application as drug delivery systems.

AB - In this paper we have evaluated a novel family of polymer-surfactant complexes formed between block ionomers and oppositely charged surfactants. Complexes between cationic copolymer poly(ethylene oxide)-g-polyethyleneimine (PEO-g-PEI) and sodium salt of oleic acid, natural nontoxic surfactant, are prepared and characterized. These systems self-assemble in aqueous solutions into particles with average size of 50-60 nm, which can solubilize hydrophobic dyes (Yellow OB) and drug molecules (paclitaxel). The use of the biologically active surfactants as components of block ionomer complexes is demonstrated for the complexes from PEO-g-PEI and all-trans-retinoic acid. Binding of relatively soluble drugs with block ionomers is illustrated using PEO-b-poly(sodium methacrylate) and doxorubicin. Overall these studies suggest that block ionomer complexes can be used to prepare a variety of soluble and stable formulations of biologically active compounds, and have potential application as drug delivery systems.

KW - All-trans- retinoic acid

KW - Block copolymers

KW - Doxorubicin

KW - Oleic acid

KW - Paclitaxel

KW - Polymer-surfactant complexes

UR - http://www.scopus.com/inward/record.url?scp=0032863454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032863454&partnerID=8YFLogxK

U2 - 10.1016/S0927-7765(99)00075-2

DO - 10.1016/S0927-7765(99)00075-2

M3 - Article

VL - 16

SP - 243

EP - 251

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

SN - 0927-7765

IS - 1-4

ER -