Not so fast

Hippocampal amnesia slows word learning despite successful fast mapping

David E Warren, Melissa C. Duff

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The human hippocampus is widely believed to be necessary for the rapid acquisition of new declarative relational memories. However, processes supporting on-line inferential word use ("fast mapping") may also exercise a dissociable learning mechanism and permit rapid word learning without the hippocampus (Sharon et al. (2011) Proc Natl Acad Sci USA 108:1146-1151). We investigated fast mapping in severely amnesic patients with hippocampal damage (N = 4), mildly amnesic patients (N = 6), and healthy comparison participants (N = 10) using on-line measures (eye movements) that reflected ongoing processing. All participants studied unique word-picture associations in two encoding conditions. In the explicit-encoding condition, uncommon items were paired with their names (e.g., "This is a numbat."). In the fast mapping study condition, participants heard an instruction using a novel word (e.g., "Click on the numbat.") while two items were presented (an uncommon target such as a numbat, and a common distracter such as a dog). All groups performed fast mapping well at study, and on-line eye movement measures did not reveal group differences. However, while comparison participants showed robust word learning irrespective of encoding condition, severely amnesic patients showed no evidence of learning after fast mapping or explicit encoding on any behavioral or eye-movement measure. Mildly amnesic patients showed some learning, but performance was unaffected by encoding condition. The findings are consistent with the following propositions: the hippocampus is not essential for on-line fast mapping of novel words; but is necessary for the rapid learning of arbitrary relational information irrespective of encoding conditions.

Original languageEnglish (US)
Pages (from-to)920-933
Number of pages14
JournalHippocampus
Volume24
Issue number8
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Amnesia
Learning
Eye Movements
Hippocampus
Names
Healthy Volunteers
Dogs
Exercise

Keywords

  • Hippocampus
  • Lexicon
  • Medial temporal lobe
  • Memory
  • Vocabulary

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Not so fast : Hippocampal amnesia slows word learning despite successful fast mapping. / Warren, David E; Duff, Melissa C.

In: Hippocampus, Vol. 24, No. 8, 01.01.2014, p. 920-933.

Research output: Contribution to journalArticle

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