Nosocomial Legionnaires' disease. Occurrence in recipients of bone marrow transplants

John W. Kugler, Jamés O. Armitage, Charles M. Helms, Lynell W. Klassen, Nancy E. Goeken, Gerald B. Ahmann, Roger D. Gingrich, William Johnson, Mary J.R. Gilchrist

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Nosocomial pneumonia caused by Legionella pneumophila serogroup 1 occurred in five patients after bone marrow transplantation for hematologic malignancies. Two patients died as a result of the infection despite treatment with erythromycin. Serologic screening revealed no other cases of Legionnaires' disease in 40 consecutive recipients of bone marrow transplants, giving a frequency of infection of 13 percent. These five cases represent 23 percent of the pneumonia occurring in this group of patients. Patients undergoing bone marrow transplantation are highly susceptible to infectious complications. Legionnaires' disease must now be added to the list of pathogens infecting this group of patients. Erythromycin is not generally a part of standard empiric antibiotic regimens in febrile neutropenic patients, but appears to be a reasonable addition when pneumonia does not respond to conventional, empiric treatment. Even with appropriate therapy, Legionnaires' disease remains a highly lethal infection in immunocompromised hosts.

Original languageEnglish (US)
Pages (from-to)281-288
Number of pages8
JournalThe American journal of medicine
Issue number2
StatePublished - Feb 1983


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kugler, J. W., Armitage, J. O., Helms, C. M., Klassen, L. W., Goeken, N. E., Ahmann, G. B., Gingrich, R. D., Johnson, W., & Gilchrist, M. J. R. (1983). Nosocomial Legionnaires' disease. Occurrence in recipients of bone marrow transplants. The American journal of medicine, 74(2), 281-288.