Nosocomial Legionnaires' disease. Occurrence in recipients of bone marrow transplants

John W. Kugler, Jamés O. Armitage, Charles M. Helms, Lynell W. Klassen, Nancy E. Goeken, Gerald B. Ahmann, Roger D. Gingrich, William Johnson, Mary J.R. Gilchrist

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Nosocomial pneumonia caused by Legionella pneumophila serogroup 1 occurred in five patients after bone marrow transplantation for hematologic malignancies. Two patients died as a result of the infection despite treatment with erythromycin. Serologic screening revealed no other cases of Legionnaires' disease in 40 consecutive recipients of bone marrow transplants, giving a frequency of infection of 13 percent. These five cases represent 23 percent of the pneumonia occurring in this group of patients. Patients undergoing bone marrow transplantation are highly susceptible to infectious complications. Legionnaires' disease must now be added to the list of pathogens infecting this group of patients. Erythromycin is not generally a part of standard empiric antibiotic regimens in febrile neutropenic patients, but appears to be a reasonable addition when pneumonia does not respond to conventional, empiric treatment. Even with appropriate therapy, Legionnaires' disease remains a highly lethal infection in immunocompromised hosts.

Original languageEnglish (US)
Pages (from-to)281-288
Number of pages8
JournalThe American journal of medicine
Volume74
Issue number2
DOIs
StatePublished - Feb 1983

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Legionnaires' Disease
Bone Marrow
Transplants
Pneumonia
Erythromycin
Bone Marrow Transplantation
Infection
Legionella pneumophila
Immunocompromised Host
Hematologic Neoplasms
Fever
Therapeutics
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nosocomial Legionnaires' disease. Occurrence in recipients of bone marrow transplants. / Kugler, John W.; Armitage, Jamés O.; Helms, Charles M.; Klassen, Lynell W.; Goeken, Nancy E.; Ahmann, Gerald B.; Gingrich, Roger D.; Johnson, William; Gilchrist, Mary J.R.

In: The American journal of medicine, Vol. 74, No. 2, 02.1983, p. 281-288.

Research output: Contribution to journalArticle

Kugler, JW, Armitage, JO, Helms, CM, Klassen, LW, Goeken, NE, Ahmann, GB, Gingrich, RD, Johnson, W & Gilchrist, MJR 1983, 'Nosocomial Legionnaires' disease. Occurrence in recipients of bone marrow transplants', The American journal of medicine, vol. 74, no. 2, pp. 281-288. https://doi.org/10.1016/0002-9343(83)90629-0
Kugler, John W. ; Armitage, Jamés O. ; Helms, Charles M. ; Klassen, Lynell W. ; Goeken, Nancy E. ; Ahmann, Gerald B. ; Gingrich, Roger D. ; Johnson, William ; Gilchrist, Mary J.R. / Nosocomial Legionnaires' disease. Occurrence in recipients of bone marrow transplants. In: The American journal of medicine. 1983 ; Vol. 74, No. 2. pp. 281-288.
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