Nonmetabolic fatigue in exercising human muscle

R. S. Moussavi, P. J. Carson, M. D. Boska, M. W. Weiner, R. G. Miller

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Human muscle fatigue, assessed by declining maximum voluntary contraction (MVC), may be caused by impairment of excitation-contraction coupling as well as by metabolic alterations within the muscle. To distinguish between these 2 possibilities, we assessed changes in excitation-contraction coupling by measuring twitch tension (TT) and twitch potentiation (P-TT) of the human adductor pollicis and tibialis anterior, while we analyzed metabolic changes using 31P magnetic resonance spectroscopy. Low-intensity exercise produced a much greater fall of TT and P-TT than MVC, high energy phosphates, or intracellular pH (pHi). In addition, the recovery of TT and P-TT was much slower than recovery of MVC, high energy phosphates, or pHi. These results suggest that the greater fall of TT and the delayed recovery following low-intensity exercise are caused by impaired excitation-contraction coupling.

Original languageEnglish (US)
Pages (from-to)1222-1226
Number of pages5
JournalNeurology
Volume39
Issue number9
StatePublished - Sep 1989

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Excitation Contraction Coupling
Fatigue
Muscles
Phosphates
Muscle Fatigue
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Moussavi, R. S., Carson, P. J., Boska, M. D., Weiner, M. W., & Miller, R. G. (1989). Nonmetabolic fatigue in exercising human muscle. Neurology, 39(9), 1222-1226.

Nonmetabolic fatigue in exercising human muscle. / Moussavi, R. S.; Carson, P. J.; Boska, M. D.; Weiner, M. W.; Miller, R. G.

In: Neurology, Vol. 39, No. 9, 09.1989, p. 1222-1226.

Research output: Contribution to journalArticle

Moussavi, RS, Carson, PJ, Boska, MD, Weiner, MW & Miller, RG 1989, 'Nonmetabolic fatigue in exercising human muscle', Neurology, vol. 39, no. 9, pp. 1222-1226.
Moussavi RS, Carson PJ, Boska MD, Weiner MW, Miller RG. Nonmetabolic fatigue in exercising human muscle. Neurology. 1989 Sep;39(9):1222-1226.
Moussavi, R. S. ; Carson, P. J. ; Boska, M. D. ; Weiner, M. W. ; Miller, R. G. / Nonmetabolic fatigue in exercising human muscle. In: Neurology. 1989 ; Vol. 39, No. 9. pp. 1222-1226.
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