Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals: Case report

Jing Xiang, Yingying Wang, Yangmei Chen, Yang Liu, Rupesh Kotecha, Xiaolin Huo, Douglas F. Rose, Hisako Fujiwara, Nat Hemasilpin, Ki Lee, Francesco T. Mangano, Blaise Jones, Ton DeGrauw

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Object. Recent reports suggest that high-frequency epileptic activity is highly localized to epileptogenic zones. The goal of the present study was to investigate the potential usefulness of noninvasive localization of high-frequency epileptic activity for epilepsy surgery. Methods. Data obtained in 4 patients, who had seizures during routine magnetoencephalography (MEG) tests, were retrospectively studied. The MEG data were digitized at 4000 Hz, and 3D MR images were obtained. The magnetic sources were volumetrically localized with wavelet-based beamformer. The MEG results were subsequently compared with clinical data. Results. The 4 patients had 1-4 high-frequency neuromagnetic components (110-910 Hz) in ictal and interictal activities. The loci of high-frequency activities were concordant with intracranial recordings therein 3 patients, who underwent presurgical evaluation. The loci of high-frequency ictal activities were in line with semiology and neuroimaging in all 4 of the patients. High-frequency epileptic activity was highly localized to the epileptogenic zones. Conclusions. High-frequency epileptic activity can be volumetrically localized with MEG. Source analysis of high-frequency neuromagnetic signals has the potential to determine epileptogenic zones noninvasively and preoperatively for epilepsy surgery.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalJournal of Neurosurgery: Pediatrics
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Magnetoencephalography
Stroke
Epilepsy
Neuroimaging
Seizures

Keywords

  • Childhood epilepsy
  • High-frequency oscillation
  • Magnetoencephalography
  • Ripple ictal activity

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals : Case report. / Xiang, Jing; Wang, Yingying; Chen, Yangmei; Liu, Yang; Kotecha, Rupesh; Huo, Xiaolin; Rose, Douglas F.; Fujiwara, Hisako; Hemasilpin, Nat; Lee, Ki; Mangano, Francesco T.; Jones, Blaise; DeGrauw, Ton.

In: Journal of Neurosurgery: Pediatrics, Vol. 5, No. 1, 01.01.2010, p. 113-122.

Research output: Contribution to journalArticle

Xiang, J, Wang, Y, Chen, Y, Liu, Y, Kotecha, R, Huo, X, Rose, DF, Fujiwara, H, Hemasilpin, N, Lee, K, Mangano, FT, Jones, B & DeGrauw, T 2010, 'Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals: Case report', Journal of Neurosurgery: Pediatrics, vol. 5, no. 1, pp. 113-122. https://doi.org/10.3171/2009.8.PEDS09345
Xiang, Jing ; Wang, Yingying ; Chen, Yangmei ; Liu, Yang ; Kotecha, Rupesh ; Huo, Xiaolin ; Rose, Douglas F. ; Fujiwara, Hisako ; Hemasilpin, Nat ; Lee, Ki ; Mangano, Francesco T. ; Jones, Blaise ; DeGrauw, Ton. / Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals : Case report. In: Journal of Neurosurgery: Pediatrics. 2010 ; Vol. 5, No. 1. pp. 113-122.
@article{9c2d8e0c83984a3aa50b1b755f2e63a5,
title = "Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals: Case report",
abstract = "Object. Recent reports suggest that high-frequency epileptic activity is highly localized to epileptogenic zones. The goal of the present study was to investigate the potential usefulness of noninvasive localization of high-frequency epileptic activity for epilepsy surgery. Methods. Data obtained in 4 patients, who had seizures during routine magnetoencephalography (MEG) tests, were retrospectively studied. The MEG data were digitized at 4000 Hz, and 3D MR images were obtained. The magnetic sources were volumetrically localized with wavelet-based beamformer. The MEG results were subsequently compared with clinical data. Results. The 4 patients had 1-4 high-frequency neuromagnetic components (110-910 Hz) in ictal and interictal activities. The loci of high-frequency activities were concordant with intracranial recordings therein 3 patients, who underwent presurgical evaluation. The loci of high-frequency ictal activities were in line with semiology and neuroimaging in all 4 of the patients. High-frequency epileptic activity was highly localized to the epileptogenic zones. Conclusions. High-frequency epileptic activity can be volumetrically localized with MEG. Source analysis of high-frequency neuromagnetic signals has the potential to determine epileptogenic zones noninvasively and preoperatively for epilepsy surgery.",
keywords = "Childhood epilepsy, High-frequency oscillation, Magnetoencephalography, Ripple ictal activity",
author = "Jing Xiang and Yingying Wang and Yangmei Chen and Yang Liu and Rupesh Kotecha and Xiaolin Huo and Rose, {Douglas F.} and Hisako Fujiwara and Nat Hemasilpin and Ki Lee and Mangano, {Francesco T.} and Blaise Jones and Ton DeGrauw",
year = "2010",
month = "1",
day = "1",
doi = "10.3171/2009.8.PEDS09345",
language = "English (US)",
volume = "5",
pages = "113--122",
journal = "Journal of Neurosurgery: Pediatrics",
issn = "1933-0707",
publisher = "American Association of Neurological Surgeons",
number = "1",

}

TY - JOUR

T1 - Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals

T2 - Case report

AU - Xiang, Jing

AU - Wang, Yingying

AU - Chen, Yangmei

AU - Liu, Yang

AU - Kotecha, Rupesh

AU - Huo, Xiaolin

AU - Rose, Douglas F.

AU - Fujiwara, Hisako

AU - Hemasilpin, Nat

AU - Lee, Ki

AU - Mangano, Francesco T.

AU - Jones, Blaise

AU - DeGrauw, Ton

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Object. Recent reports suggest that high-frequency epileptic activity is highly localized to epileptogenic zones. The goal of the present study was to investigate the potential usefulness of noninvasive localization of high-frequency epileptic activity for epilepsy surgery. Methods. Data obtained in 4 patients, who had seizures during routine magnetoencephalography (MEG) tests, were retrospectively studied. The MEG data were digitized at 4000 Hz, and 3D MR images were obtained. The magnetic sources were volumetrically localized with wavelet-based beamformer. The MEG results were subsequently compared with clinical data. Results. The 4 patients had 1-4 high-frequency neuromagnetic components (110-910 Hz) in ictal and interictal activities. The loci of high-frequency activities were concordant with intracranial recordings therein 3 patients, who underwent presurgical evaluation. The loci of high-frequency ictal activities were in line with semiology and neuroimaging in all 4 of the patients. High-frequency epileptic activity was highly localized to the epileptogenic zones. Conclusions. High-frequency epileptic activity can be volumetrically localized with MEG. Source analysis of high-frequency neuromagnetic signals has the potential to determine epileptogenic zones noninvasively and preoperatively for epilepsy surgery.

AB - Object. Recent reports suggest that high-frequency epileptic activity is highly localized to epileptogenic zones. The goal of the present study was to investigate the potential usefulness of noninvasive localization of high-frequency epileptic activity for epilepsy surgery. Methods. Data obtained in 4 patients, who had seizures during routine magnetoencephalography (MEG) tests, were retrospectively studied. The MEG data were digitized at 4000 Hz, and 3D MR images were obtained. The magnetic sources were volumetrically localized with wavelet-based beamformer. The MEG results were subsequently compared with clinical data. Results. The 4 patients had 1-4 high-frequency neuromagnetic components (110-910 Hz) in ictal and interictal activities. The loci of high-frequency activities were concordant with intracranial recordings therein 3 patients, who underwent presurgical evaluation. The loci of high-frequency ictal activities were in line with semiology and neuroimaging in all 4 of the patients. High-frequency epileptic activity was highly localized to the epileptogenic zones. Conclusions. High-frequency epileptic activity can be volumetrically localized with MEG. Source analysis of high-frequency neuromagnetic signals has the potential to determine epileptogenic zones noninvasively and preoperatively for epilepsy surgery.

KW - Childhood epilepsy

KW - High-frequency oscillation

KW - Magnetoencephalography

KW - Ripple ictal activity

UR - http://www.scopus.com/inward/record.url?scp=75449091630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75449091630&partnerID=8YFLogxK

U2 - 10.3171/2009.8.PEDS09345

DO - 10.3171/2009.8.PEDS09345

M3 - Article

C2 - 20043746

AN - SCOPUS:75449091630

VL - 5

SP - 113

EP - 122

JO - Journal of Neurosurgery: Pediatrics

JF - Journal of Neurosurgery: Pediatrics

SN - 1933-0707

IS - 1

ER -