Noninvasive Diagnosis of Coronary Artery Bypass Graft Disease by Dobutamine Stress Real-time Myocardial Contrast Perfusion Imaging

Abdou Elhendy, Jeane M. Tsutsui, Edward Lewis O'Leary, Feng Xie, Thomas Richard Porter

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The aim of this study was to assess the accuracy of real-time myocardial contrast perfusion imaging (MCPI) during dobutamine stress echocardiography, for the diagnosis of coronary artery bypass graft disease. Methods: MCPI was performed using commercially available ultrasound contrast agents (Optison or Definity) at rest and at peak dobutamine-atropine stress in 64 patients with previous coronary artery bypass graft. Significant disease was defined as 70% or greater stenosis in one or more grafts or a native nongrafted coronary artery. MCPI was considered diagnostic in the presence of reversible perfusion abnormalities (RPA). Results: Significant stenosis (≥70% by quantitative angiography) in one or more grafts was detected in 49 patients (77%). RPA were detected in 44 of these patients (sensitivity 90%, confidence interval [CI] 81-98). Significant stenosis was detected in 74 of the 176 bypass grafts (42%). RPA were detected in the distribution of 55 diseased grafts and 21 nondiseased grafts (regional sensitivity 74%, CI 64-84; specificity 79%, CI 71-87; and accuracy 77%, CI 71-84). RPA were detected in two or more vascular distributions in 25 of 33 patients with multivessel stenotic lesions and in 4 of 31 patients without (sensitivity 76%, CI 61-90; specificity 87%, CI 75-99; and accuracy 81%, CI 72-91). Conclusion: Dobutamine stress MCPI is a useful technique for the evaluation of coronary artery bypass graft disease.

Original languageEnglish (US)
Pages (from-to)1482-1487
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume19
Issue number12
DOIs
StatePublished - Dec 1 2006

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Myocardial Perfusion Imaging
Dobutamine
Coronary Artery Bypass
Transplants
Confidence Intervals
Perfusion
Pathologic Constriction
Stress Echocardiography
Atropine
Contrast Media
Blood Vessels
Coronary Vessels
Angiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{eb33eea9f9b6453cbe16712b8978dbf1,
title = "Noninvasive Diagnosis of Coronary Artery Bypass Graft Disease by Dobutamine Stress Real-time Myocardial Contrast Perfusion Imaging",
abstract = "Background: The aim of this study was to assess the accuracy of real-time myocardial contrast perfusion imaging (MCPI) during dobutamine stress echocardiography, for the diagnosis of coronary artery bypass graft disease. Methods: MCPI was performed using commercially available ultrasound contrast agents (Optison or Definity) at rest and at peak dobutamine-atropine stress in 64 patients with previous coronary artery bypass graft. Significant disease was defined as 70{\%} or greater stenosis in one or more grafts or a native nongrafted coronary artery. MCPI was considered diagnostic in the presence of reversible perfusion abnormalities (RPA). Results: Significant stenosis (≥70{\%} by quantitative angiography) in one or more grafts was detected in 49 patients (77{\%}). RPA were detected in 44 of these patients (sensitivity 90{\%}, confidence interval [CI] 81-98). Significant stenosis was detected in 74 of the 176 bypass grafts (42{\%}). RPA were detected in the distribution of 55 diseased grafts and 21 nondiseased grafts (regional sensitivity 74{\%}, CI 64-84; specificity 79{\%}, CI 71-87; and accuracy 77{\%}, CI 71-84). RPA were detected in two or more vascular distributions in 25 of 33 patients with multivessel stenotic lesions and in 4 of 31 patients without (sensitivity 76{\%}, CI 61-90; specificity 87{\%}, CI 75-99; and accuracy 81{\%}, CI 72-91). Conclusion: Dobutamine stress MCPI is a useful technique for the evaluation of coronary artery bypass graft disease.",
author = "Abdou Elhendy and Tsutsui, {Jeane M.} and O'Leary, {Edward Lewis} and Feng Xie and Porter, {Thomas Richard}",
year = "2006",
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doi = "10.1016/j.echo.2006.06.005",
language = "English (US)",
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pages = "1482--1487",
journal = "Journal of the American Society of Echocardiography",
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T1 - Noninvasive Diagnosis of Coronary Artery Bypass Graft Disease by Dobutamine Stress Real-time Myocardial Contrast Perfusion Imaging

AU - Elhendy, Abdou

AU - Tsutsui, Jeane M.

AU - O'Leary, Edward Lewis

AU - Xie, Feng

AU - Porter, Thomas Richard

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Background: The aim of this study was to assess the accuracy of real-time myocardial contrast perfusion imaging (MCPI) during dobutamine stress echocardiography, for the diagnosis of coronary artery bypass graft disease. Methods: MCPI was performed using commercially available ultrasound contrast agents (Optison or Definity) at rest and at peak dobutamine-atropine stress in 64 patients with previous coronary artery bypass graft. Significant disease was defined as 70% or greater stenosis in one or more grafts or a native nongrafted coronary artery. MCPI was considered diagnostic in the presence of reversible perfusion abnormalities (RPA). Results: Significant stenosis (≥70% by quantitative angiography) in one or more grafts was detected in 49 patients (77%). RPA were detected in 44 of these patients (sensitivity 90%, confidence interval [CI] 81-98). Significant stenosis was detected in 74 of the 176 bypass grafts (42%). RPA were detected in the distribution of 55 diseased grafts and 21 nondiseased grafts (regional sensitivity 74%, CI 64-84; specificity 79%, CI 71-87; and accuracy 77%, CI 71-84). RPA were detected in two or more vascular distributions in 25 of 33 patients with multivessel stenotic lesions and in 4 of 31 patients without (sensitivity 76%, CI 61-90; specificity 87%, CI 75-99; and accuracy 81%, CI 72-91). Conclusion: Dobutamine stress MCPI is a useful technique for the evaluation of coronary artery bypass graft disease.

AB - Background: The aim of this study was to assess the accuracy of real-time myocardial contrast perfusion imaging (MCPI) during dobutamine stress echocardiography, for the diagnosis of coronary artery bypass graft disease. Methods: MCPI was performed using commercially available ultrasound contrast agents (Optison or Definity) at rest and at peak dobutamine-atropine stress in 64 patients with previous coronary artery bypass graft. Significant disease was defined as 70% or greater stenosis in one or more grafts or a native nongrafted coronary artery. MCPI was considered diagnostic in the presence of reversible perfusion abnormalities (RPA). Results: Significant stenosis (≥70% by quantitative angiography) in one or more grafts was detected in 49 patients (77%). RPA were detected in 44 of these patients (sensitivity 90%, confidence interval [CI] 81-98). Significant stenosis was detected in 74 of the 176 bypass grafts (42%). RPA were detected in the distribution of 55 diseased grafts and 21 nondiseased grafts (regional sensitivity 74%, CI 64-84; specificity 79%, CI 71-87; and accuracy 77%, CI 71-84). RPA were detected in two or more vascular distributions in 25 of 33 patients with multivessel stenotic lesions and in 4 of 31 patients without (sensitivity 76%, CI 61-90; specificity 87%, CI 75-99; and accuracy 81%, CI 72-91). Conclusion: Dobutamine stress MCPI is a useful technique for the evaluation of coronary artery bypass graft disease.

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