Nonhomologous pairing in mice heterozygous for a T haplotype can produce recombinant chromosomes with duplications and deletions

Nora E Sarvetnick, Howard S Fox, E. Mann, P. E. Mains, R. W. Elliott, L. M. Silver

Research output: Contribution to journalArticle

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Abstract

We have investigated the structure and properties of a chromosomal product recovered from a rare recombination event between a t haplotype and a wild-type form of mouse chromosome 17. Our embryological and molecular studies indicate that this chromosome (t(wLub2)) is characterized by both a deletion and duplication of adjacent genetic material. The deletion appears to be responsible for a dominant lethal maternal effect and a recessive embryonic lethality. The duplication provides an explanation for the t(wLub2) suppression of the dominant T locus phenotype. A reanalysis of previously described results with another chromosome 17 variant called Tt(Orl) indicates a structure for this chromosome that is reciprocal to that observed for t(wLub2). We have postulated the existence of an inversion over the proximal portion of all complete t haplotypes in order to explain the generation of the partial t haplotypes t(wLub2) and Tt(Orl). This proximal inversion and the previously described distal inversion are sufficient to account for all of the recombination properties that are characteristic of complete t haplotypes. The structures determined for t(wLub2) and Tt(Orl) indicate that rare recombination can occur between nonequivalent genomic sequences within the inverted proximal t region when wild-type and t chromosomes are paired in a linear, nonhomologous configuration.

Original languageEnglish (US)
Pages (from-to)723-734
Number of pages12
JournalGenetics
Volume113
Issue number3
StatePublished - Dec 3 1986
Externally publishedYes

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Chromosome Duplication
Chromosome Deletion
Haplotypes
Genetic Recombination
Chromosomes, Human, Pair 17
Chromosomes
Sequence Inversion
Chromosome Structures
Phenotype
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Nonhomologous pairing in mice heterozygous for a T haplotype can produce recombinant chromosomes with duplications and deletions. / Sarvetnick, Nora E; Fox, Howard S; Mann, E.; Mains, P. E.; Elliott, R. W.; Silver, L. M.

In: Genetics, Vol. 113, No. 3, 03.12.1986, p. 723-734.

Research output: Contribution to journalArticle

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AU - Fox, Howard S

AU - Mann, E.

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AU - Elliott, R. W.

AU - Silver, L. M.

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