Nonabsorbable Corticosteroids Use in the Treatment of Gastrointestinal Graft-versus-Host Disease

Rami B. Ibrahim, Muneer H. Abidi, Simon M. Cronin, Lawrence G. Lum, Zaid S Al-Kadhimi, Voravit Ratanatharathorn, Joseph P. Uberti

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

For over a decade, nonabsorbable corticosteroids have been employed in the treatment of gastrointestinal graft-versus-host-disease (GVHD) in hematopoietic stem cell transplant (HSCT), as monotherapy or in combination with systemic corticosteroids. The majority of the evidence showing a favorable outcome consisted of case series, small phase II trials and a large randomized phase III trial. The 2 most commonly studied molecules were oral budesonide and beclomethasone diproprionate. Although these reports hint at some benefit with the local treatment strategy, their methodologic inconsistencies preclude meaningful adoption to everyday clinical practice. This review evaluates the current evidence of nonabsorbable corticosteroids in HSCT and sets forth recommendations for future trials with these agents.

Original languageEnglish (US)
Pages (from-to)395-405
Number of pages11
JournalBiology of Blood and Marrow Transplantation
Volume15
Issue number4
DOIs
StatePublished - Apr 1 2009

Fingerprint

Graft vs Host Disease
Adrenal Cortex Hormones
Hematopoietic Stem Cells
Transplants
Beclomethasone
Budesonide

Keywords

  • Beclomethasone dipropionate
  • Budesonide
  • GVGD
  • Gastrointestinal
  • Hematopoietic
  • Transplant

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Nonabsorbable Corticosteroids Use in the Treatment of Gastrointestinal Graft-versus-Host Disease. / Ibrahim, Rami B.; Abidi, Muneer H.; Cronin, Simon M.; Lum, Lawrence G.; Al-Kadhimi, Zaid S; Ratanatharathorn, Voravit; Uberti, Joseph P.

In: Biology of Blood and Marrow Transplantation, Vol. 15, No. 4, 01.04.2009, p. 395-405.

Research output: Contribution to journalReview article

Ibrahim, Rami B. ; Abidi, Muneer H. ; Cronin, Simon M. ; Lum, Lawrence G. ; Al-Kadhimi, Zaid S ; Ratanatharathorn, Voravit ; Uberti, Joseph P. / Nonabsorbable Corticosteroids Use in the Treatment of Gastrointestinal Graft-versus-Host Disease. In: Biology of Blood and Marrow Transplantation. 2009 ; Vol. 15, No. 4. pp. 395-405.
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