Non-sarcoid granulomatous disease with involvement of the lungs.

G. Müns, William Walter West, J. Gurney, Stephen Israel Rennard

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Pulmonary granulomatous disease can severely damage the lungs and represents a rather uniform response of the lungs to a multitude of different stimuli. Histologically, granulomatas can be broadly classified as either hypersensitivity-type or foreign-body-type. A wide variety of infectious and non-infectious etiologies discussed in this review have been identified as causes of granulomatous inflammation of the lungs. An infectious origin should always be excluded since specific etiologic therapy may be implemented. Culture techniques for microorganisms or fungi and standard or special stains of tissue samples are crucial to establish the specific etiologies. The mechanisms leading to granuloma formation are still poorly understood, but the role of parenchymal cells, fibroblasts, endothelial and epithelial cells, and cytokines, has been better appreciated; all of them are important in the initiation, maintenance, and resolution of the lesion. Whether these new insights will finally lead to new ways of treating lung granuloma remains to be determined.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalSarcoidosis
Volume12
Issue number2
StatePublished - Jan 1 1995

Fingerprint

Granuloma
Lung
Somatotypes
Culture Techniques
Foreign Bodies
Lung Diseases
Pneumonia
Hypersensitivity
Fungi
Coloring Agents
Endothelial Cells
Fibroblasts
Epithelial Cells
Maintenance
Cytokines
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Müns, G., West, W. W., Gurney, J., & Rennard, S. I. (1995). Non-sarcoid granulomatous disease with involvement of the lungs. Sarcoidosis, 12(2), 99-110.

Non-sarcoid granulomatous disease with involvement of the lungs. / Müns, G.; West, William Walter; Gurney, J.; Rennard, Stephen Israel.

In: Sarcoidosis, Vol. 12, No. 2, 01.01.1995, p. 99-110.

Research output: Contribution to journalReview article

Müns, G, West, WW, Gurney, J & Rennard, SI 1995, 'Non-sarcoid granulomatous disease with involvement of the lungs.', Sarcoidosis, vol. 12, no. 2, pp. 99-110.
Müns G, West WW, Gurney J, Rennard SI. Non-sarcoid granulomatous disease with involvement of the lungs. Sarcoidosis. 1995 Jan 1;12(2):99-110.
Müns, G. ; West, William Walter ; Gurney, J. ; Rennard, Stephen Israel. / Non-sarcoid granulomatous disease with involvement of the lungs. In: Sarcoidosis. 1995 ; Vol. 12, No. 2. pp. 99-110.
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