Non-Hodgkin lymphoma in the Far East: review of 730 cases from the international non-Hodgkin lymphoma classification project

Anamarija M. Perry, Jacques Diebold, Bharat N. Nathwani, Kenneth A. MacLennan, Hans K. Müller-Hermelink, Martin Bast, Eugene Boilesen, James Olen Armitage, Dennis D. Weisenburger

Research output: Contribution to journalArticle

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Abstract

Large and systematic studies of non-Hodgkin lymphoma (NHL) in the Far East (FE) with good comparative data are scarce in the literature. In this study, five expert hematopathologists classified 730 consecutive cases of newly-diagnosed NHL from four sites in the FE (excluding Japan) using the World Health Organization classification. The results were compared to 399 cases from North America (NA). We found a significantly higher male to female ratio in the FE compared to NA (1.7 versus 1.1; p < 0.05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in the FE (58 and 51 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). The FE had a significantly lower relative frequency of B-NHL and a higher frequency of T-NHL (82 vs. 18 %) compared to NA (90.5 vs. 9.5 %). Among mature B cell lymphomas, the FE had a significantly higher relative frequency of HG B-NHL (54.8 %) and a lower frequency of LG B-NHL (27.2 %) than NA (34.3 and 56.1 %, respectively). Diffuse large B cell lymphoma was more common in the FE (49.4 %) compared to NA (29.3 %), whereas the relative frequency of follicular lymphoma was lower in the FE (9.4 %) compared to NA (33.6 %). Among T-NHL, nasal NK/T cell NHL was more frequent in the FE (5.2 %) compared to NA (0 %). Peripheral T cell lymphoma was also more common in the FE (9.1 %) than in NA (5.3 %). Further epidemiologic studies are needed to better understand the pathobiology of these differences.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalAnnals of Hematology
Volume95
Issue number2
DOIs
StatePublished - Jan 1 2016

Fingerprint

Far East
Non-Hodgkin's Lymphoma
North America
Peripheral T-Cell Lymphoma
Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
T-Cell Lymphoma
B-Cell Lymphoma
Nose
Natural Killer Cells
Epidemiologic Studies
Japan

Keywords

  • Epidemiology
  • Far East
  • Non-Hodgkin lymphoma
  • North America

ASJC Scopus subject areas

  • Hematology

Cite this

Perry, A. M., Diebold, J., Nathwani, B. N., MacLennan, K. A., Müller-Hermelink, H. K., Bast, M., ... Weisenburger, D. D. (2016). Non-Hodgkin lymphoma in the Far East: review of 730 cases from the international non-Hodgkin lymphoma classification project. Annals of Hematology, 95(2), 245-251. https://doi.org/10.1007/s00277-015-2543-4

Non-Hodgkin lymphoma in the Far East : review of 730 cases from the international non-Hodgkin lymphoma classification project. / Perry, Anamarija M.; Diebold, Jacques; Nathwani, Bharat N.; MacLennan, Kenneth A.; Müller-Hermelink, Hans K.; Bast, Martin; Boilesen, Eugene; Armitage, James Olen; Weisenburger, Dennis D.

In: Annals of Hematology, Vol. 95, No. 2, 01.01.2016, p. 245-251.

Research output: Contribution to journalArticle

Perry, AM, Diebold, J, Nathwani, BN, MacLennan, KA, Müller-Hermelink, HK, Bast, M, Boilesen, E, Armitage, JO & Weisenburger, DD 2016, 'Non-Hodgkin lymphoma in the Far East: review of 730 cases from the international non-Hodgkin lymphoma classification project', Annals of Hematology, vol. 95, no. 2, pp. 245-251. https://doi.org/10.1007/s00277-015-2543-4
Perry, Anamarija M. ; Diebold, Jacques ; Nathwani, Bharat N. ; MacLennan, Kenneth A. ; Müller-Hermelink, Hans K. ; Bast, Martin ; Boilesen, Eugene ; Armitage, James Olen ; Weisenburger, Dennis D. / Non-Hodgkin lymphoma in the Far East : review of 730 cases from the international non-Hodgkin lymphoma classification project. In: Annals of Hematology. 2016 ; Vol. 95, No. 2. pp. 245-251.
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abstract = "Large and systematic studies of non-Hodgkin lymphoma (NHL) in the Far East (FE) with good comparative data are scarce in the literature. In this study, five expert hematopathologists classified 730 consecutive cases of newly-diagnosed NHL from four sites in the FE (excluding Japan) using the World Health Organization classification. The results were compared to 399 cases from North America (NA). We found a significantly higher male to female ratio in the FE compared to NA (1.7 versus 1.1; p < 0.05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in the FE (58 and 51 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). The FE had a significantly lower relative frequency of B-NHL and a higher frequency of T-NHL (82 vs. 18 {\%}) compared to NA (90.5 vs. 9.5 {\%}). Among mature B cell lymphomas, the FE had a significantly higher relative frequency of HG B-NHL (54.8 {\%}) and a lower frequency of LG B-NHL (27.2 {\%}) than NA (34.3 and 56.1 {\%}, respectively). Diffuse large B cell lymphoma was more common in the FE (49.4 {\%}) compared to NA (29.3 {\%}), whereas the relative frequency of follicular lymphoma was lower in the FE (9.4 {\%}) compared to NA (33.6 {\%}). Among T-NHL, nasal NK/T cell NHL was more frequent in the FE (5.2 {\%}) compared to NA (0 {\%}). Peripheral T cell lymphoma was also more common in the FE (9.1 {\%}) than in NA (5.3 {\%}). Further epidemiologic studies are needed to better understand the pathobiology of these differences.",
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