Non-Hodgkin lymphoma in Southern Africa

Review of 487 cases from The International Non-Hodgkin Lymphoma Classification Project

Anamarija M. Perry, Yvonne Perner, Jacques Diebold, Bharat N. Nathwani, Kenneth A. Maclennan, Hans K. Müller-Hermelink, Martin Bast, Eugene Boilesen, James Olen Armitage, Dennis D. Weisenburger

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Comparative data on the distribution of non-Hodgkin lymphoma (NHL) subtypes in Southern Africa (SAF) is scarce. In this study, five expert haematopathologists classified 487 consecutive cases of NHL from SAF using the World Health Organization classification, and compared the results to North America (NA) and Western Europe (WEU). Southern Africa had a significantly lower proportion of low-grade (LG) B-NHL (34·3%) and a higher proportion of high-grade (HG) B-NHL (51·5%) compared to WEU (54·5% and 36·4%) and NA (56·1% and 34·3%). High-grade Burkitt-like lymphoma was significantly more common in SAF (8·2%) than in WEU (2·4%) and NA (2·5%), most likely due to human immunodeficiency virus infection. When SAF patients were divided by race, whites had a significantly higher frequency of LG B-NHL (60·4%) and a lower frequency of HG B-NHL (32·7%) compared to blacks (22·5% and 62·6%), whereas the other races were intermediate. Whites and other races had a significantly higher frequency of follicular lymphoma and a lower frequency of Burkitt-like lymphoma compared to blacks. The median ages of whites with LG B-NHL, HG B-NHL and T-NHL (64, 56 and 67 years) were significantly higher than those of blacks (55, 41 and 34 years). Epidemiological studies are needed to better understand these differences.

Original languageEnglish (US)
Pages (from-to)716-723
Number of pages8
JournalBritish Journal of Haematology
Volume172
Issue number5
DOIs
StatePublished - Mar 1 2016

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Southern Africa
Non-Hodgkin's Lymphoma
North America
Burkitt Lymphoma
Follicular Lymphoma
Virus Diseases
Epidemiologic Studies
HIV

Keywords

  • Epidemiology
  • Non-Hodgkin lymphoma
  • South Africa
  • Southern Africa
  • Zimbabwe

ASJC Scopus subject areas

  • Hematology

Cite this

Perry, A. M., Perner, Y., Diebold, J., Nathwani, B. N., Maclennan, K. A., Müller-Hermelink, H. K., ... Weisenburger, D. D. (2016). Non-Hodgkin lymphoma in Southern Africa: Review of 487 cases from The International Non-Hodgkin Lymphoma Classification Project. British Journal of Haematology, 172(5), 716-723. https://doi.org/10.1111/bjh.13885

Non-Hodgkin lymphoma in Southern Africa : Review of 487 cases from The International Non-Hodgkin Lymphoma Classification Project. / Perry, Anamarija M.; Perner, Yvonne; Diebold, Jacques; Nathwani, Bharat N.; Maclennan, Kenneth A.; Müller-Hermelink, Hans K.; Bast, Martin; Boilesen, Eugene; Armitage, James Olen; Weisenburger, Dennis D.

In: British Journal of Haematology, Vol. 172, No. 5, 01.03.2016, p. 716-723.

Research output: Contribution to journalArticle

Perry, AM, Perner, Y, Diebold, J, Nathwani, BN, Maclennan, KA, Müller-Hermelink, HK, Bast, M, Boilesen, E, Armitage, JO & Weisenburger, DD 2016, 'Non-Hodgkin lymphoma in Southern Africa: Review of 487 cases from The International Non-Hodgkin Lymphoma Classification Project', British Journal of Haematology, vol. 172, no. 5, pp. 716-723. https://doi.org/10.1111/bjh.13885
Perry, Anamarija M. ; Perner, Yvonne ; Diebold, Jacques ; Nathwani, Bharat N. ; Maclennan, Kenneth A. ; Müller-Hermelink, Hans K. ; Bast, Martin ; Boilesen, Eugene ; Armitage, James Olen ; Weisenburger, Dennis D. / Non-Hodgkin lymphoma in Southern Africa : Review of 487 cases from The International Non-Hodgkin Lymphoma Classification Project. In: British Journal of Haematology. 2016 ; Vol. 172, No. 5. pp. 716-723.
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abstract = "Comparative data on the distribution of non-Hodgkin lymphoma (NHL) subtypes in Southern Africa (SAF) is scarce. In this study, five expert haematopathologists classified 487 consecutive cases of NHL from SAF using the World Health Organization classification, and compared the results to North America (NA) and Western Europe (WEU). Southern Africa had a significantly lower proportion of low-grade (LG) B-NHL (34·3{\%}) and a higher proportion of high-grade (HG) B-NHL (51·5{\%}) compared to WEU (54·5{\%} and 36·4{\%}) and NA (56·1{\%} and 34·3{\%}). High-grade Burkitt-like lymphoma was significantly more common in SAF (8·2{\%}) than in WEU (2·4{\%}) and NA (2·5{\%}), most likely due to human immunodeficiency virus infection. When SAF patients were divided by race, whites had a significantly higher frequency of LG B-NHL (60·4{\%}) and a lower frequency of HG B-NHL (32·7{\%}) compared to blacks (22·5{\%} and 62·6{\%}), whereas the other races were intermediate. Whites and other races had a significantly higher frequency of follicular lymphoma and a lower frequency of Burkitt-like lymphoma compared to blacks. The median ages of whites with LG B-NHL, HG B-NHL and T-NHL (64, 56 and 67 years) were significantly higher than those of blacks (55, 41 and 34 years). Epidemiological studies are needed to better understand these differences.",
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