Non-Hodgkin lymphoma in Chile: A review of 207 consecutive adult cases by a panel of five expert hematopathologists

Maria Elena Cabrera, Virginia Martinez, Bharat N. Nathwani, H. Konrad Muller-Hermelink, Jacques Diebold, Kenneth A. MacLennan, James Olen Armitage, Dennis D. Weisenburger

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The distribution of subtypes of non-Hodgkin lymphoma (NHL) in Latin America is not well known. This Chilean study included 207 consecutive cases of NHL diagnosed at five cancer centers in the capital, Santiago, and one center in Viña del Mar. All cases were reviewed and classified independently by five expert hematopathologists according to the 2001 World Health Organization classification of NHL. A consensus diagnosis of NHL was reached in 195 of the 207 cases (94%). B-cell lymphomas constituted 88% of NHL, and diffuse large B-cell lymphoma (DLBCL, 38.5%) and follicular lymphoma (25.1%) were the most common subtypes. There was a high frequency of marginal zone B-cell lymphoma (10.3%), as well as of extranodal natural killer (NK)/T-cell lymphoma, nasal type (2.6%) and adult T-cell leukemia/lymphoma (0.5%). Extranodal presentation was seen in 74 of the 195 cases (38%) and the most common extranodal presentation was in the stomach (37.6%). The most common gastric lymphoma was DLBCL (54.5%) followed by mucosa-associated lymphoid tissue (MALT) lymphoma (41%). Overall, the frequency of NHL subtypes in Chile is between that reported in Western and Eastern countries, which is probably a reflection of the admixture of ethnicities as well as the environment and socioeconomic status of its population.

Original languageEnglish (US)
Pages (from-to)1311-1317
Number of pages7
JournalLeukemia and Lymphoma
Volume53
Issue number7
DOIs
StatePublished - Jul 1 2012

Fingerprint

Chile
Non-Hodgkin's Lymphoma
Marginal Zone B-Cell Lymphoma
Adult T Cell Leukemia Lymphoma
Follicular Lymphoma
Natural Killer T-Cells
Lymphoma, Large B-Cell, Diffuse
Latin America
T-Cell Lymphoma
B-Cell Lymphoma
Nose
Social Class
Stomach
Economics
Population
Neoplasms

Keywords

  • B-cell lymphoma
  • Chile
  • Non-Hodgkin lymphoma
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Cabrera, M. E., Martinez, V., Nathwani, B. N., Muller-Hermelink, H. K., Diebold, J., MacLennan, K. A., ... Weisenburger, D. D. (2012). Non-Hodgkin lymphoma in Chile: A review of 207 consecutive adult cases by a panel of five expert hematopathologists. Leukemia and Lymphoma, 53(7), 1311-1317. https://doi.org/10.3109/10428194.2012.654471

Non-Hodgkin lymphoma in Chile : A review of 207 consecutive adult cases by a panel of five expert hematopathologists. / Cabrera, Maria Elena; Martinez, Virginia; Nathwani, Bharat N.; Muller-Hermelink, H. Konrad; Diebold, Jacques; MacLennan, Kenneth A.; Armitage, James Olen; Weisenburger, Dennis D.

In: Leukemia and Lymphoma, Vol. 53, No. 7, 01.07.2012, p. 1311-1317.

Research output: Contribution to journalArticle

Cabrera, ME, Martinez, V, Nathwani, BN, Muller-Hermelink, HK, Diebold, J, MacLennan, KA, Armitage, JO & Weisenburger, DD 2012, 'Non-Hodgkin lymphoma in Chile: A review of 207 consecutive adult cases by a panel of five expert hematopathologists', Leukemia and Lymphoma, vol. 53, no. 7, pp. 1311-1317. https://doi.org/10.3109/10428194.2012.654471
Cabrera ME, Martinez V, Nathwani BN, Muller-Hermelink HK, Diebold J, MacLennan KA et al. Non-Hodgkin lymphoma in Chile: A review of 207 consecutive adult cases by a panel of five expert hematopathologists. Leukemia and Lymphoma. 2012 Jul 1;53(7):1311-1317. https://doi.org/10.3109/10428194.2012.654471
Cabrera, Maria Elena ; Martinez, Virginia ; Nathwani, Bharat N. ; Muller-Hermelink, H. Konrad ; Diebold, Jacques ; MacLennan, Kenneth A. ; Armitage, James Olen ; Weisenburger, Dennis D. / Non-Hodgkin lymphoma in Chile : A review of 207 consecutive adult cases by a panel of five expert hematopathologists. In: Leukemia and Lymphoma. 2012 ; Vol. 53, No. 7. pp. 1311-1317.
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