Esteatohepatitis no alcohólica

Experiencia de 10 años en el Instituto Nacional de la Nutrición Salvador Zubirán.

Translated title of the contribution: Non-alcoholic fatty liver: 10 years' experience at the Insituto Nacional de la Nutrición Salvador Zubirán

G. de la Mora, Marco A Olivera-Martinez, R. de la Cerda, J. Arista, D. Kershenobich, M. Uribe

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

AIM. To describe the characteristics of non-alcoholic steatohepatitis (NASH) at the Instituto Nacional de la Nutricion Salvador Zubiran. MATERIAL AND METHODS. We reviewed all liver biopsy reports from January 1982 to December 1991. From patient records we obtained the following data: clinical, biochemical, imaging studies and we reviewed the histological material. We correlated clinical, biochemical and histological data. RESULTS. From 2963 biopsies reviewed we obtained 16 cases of NASH. We found a 7:1 female/male ratio. Median age was 30 years and six patients were obese. Eleven patients had concomitant disease (diabetes in seven) and nine were using drugs. All had been studied for biochemical abnormalities and were asymptomatic. Ten patients had hepatomegaly and six splenomegaly. Ultrasound suggested the diagnosis in 50% of the cases. All had steatosis, inflammatory infiltrate, necrosis, fibrosis and Mallory bodies at different stages. One case had cirrhosis on initial biopsy and two developed cirrhosis on follow-up (one and eight years later). We did not find any correlation between clinical, biochemical or imaging characteristics and histological findings. When we compared these findings between obese and non obese patients and primary and secondary NASH we did not find any differences between groups. CONCLUSIONS. NASH is infrequent in our institution. The underlying pathogenesis seems to be multifactorial. There is no biochemical-histological correlation. Cirrhosis can develop in some cases.

Original languageSpanish
Pages (from-to)85-92
Number of pages8
JournalRevista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
Volume46
Issue number2
StatePublished - Jan 1 1994

Fingerprint

Fatty Liver
Fibrosis
Biopsy
Mallory Bodies
Hepatomegaly
Splenomegaly
Necrosis
Liver
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Esteatohepatitis no alcohólica : Experiencia de 10 años en el Instituto Nacional de la Nutrición Salvador Zubirán. / de la Mora, G.; Olivera-Martinez, Marco A; de la Cerda, R.; Arista, J.; Kershenobich, D.; Uribe, M.

In: Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición, Vol. 46, No. 2, 01.01.1994, p. 85-92.

Research output: Contribution to journalReview article

@article{01dc9635d26d4d9e969369b1a1cf3fa7,
title = "Esteatohepatitis no alcoh{\'o}lica: Experiencia de 10 a{\~n}os en el Instituto Nacional de la Nutrici{\'o}n Salvador Zubir{\'a}n.",
abstract = "AIM. To describe the characteristics of non-alcoholic steatohepatitis (NASH) at the Instituto Nacional de la Nutricion Salvador Zubiran. MATERIAL AND METHODS. We reviewed all liver biopsy reports from January 1982 to December 1991. From patient records we obtained the following data: clinical, biochemical, imaging studies and we reviewed the histological material. We correlated clinical, biochemical and histological data. RESULTS. From 2963 biopsies reviewed we obtained 16 cases of NASH. We found a 7:1 female/male ratio. Median age was 30 years and six patients were obese. Eleven patients had concomitant disease (diabetes in seven) and nine were using drugs. All had been studied for biochemical abnormalities and were asymptomatic. Ten patients had hepatomegaly and six splenomegaly. Ultrasound suggested the diagnosis in 50{\%} of the cases. All had steatosis, inflammatory infiltrate, necrosis, fibrosis and Mallory bodies at different stages. One case had cirrhosis on initial biopsy and two developed cirrhosis on follow-up (one and eight years later). We did not find any correlation between clinical, biochemical or imaging characteristics and histological findings. When we compared these findings between obese and non obese patients and primary and secondary NASH we did not find any differences between groups. CONCLUSIONS. NASH is infrequent in our institution. The underlying pathogenesis seems to be multifactorial. There is no biochemical-histological correlation. Cirrhosis can develop in some cases.",
author = "{de la Mora}, G. and Olivera-Martinez, {Marco A} and {de la Cerda}, R. and J. Arista and D. Kershenobich and M. Uribe",
year = "1994",
month = "1",
day = "1",
language = "Spanish",
volume = "46",
pages = "85--92",
journal = "Revista de Investigacion Clinica",
issn = "0034-8376",
publisher = "Instituto Nacional de la Nutricion Salvador Zubiran",
number = "2",

}

TY - JOUR

T1 - Esteatohepatitis no alcohólica

T2 - Experiencia de 10 años en el Instituto Nacional de la Nutrición Salvador Zubirán.

AU - de la Mora, G.

AU - Olivera-Martinez, Marco A

AU - de la Cerda, R.

AU - Arista, J.

AU - Kershenobich, D.

AU - Uribe, M.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - AIM. To describe the characteristics of non-alcoholic steatohepatitis (NASH) at the Instituto Nacional de la Nutricion Salvador Zubiran. MATERIAL AND METHODS. We reviewed all liver biopsy reports from January 1982 to December 1991. From patient records we obtained the following data: clinical, biochemical, imaging studies and we reviewed the histological material. We correlated clinical, biochemical and histological data. RESULTS. From 2963 biopsies reviewed we obtained 16 cases of NASH. We found a 7:1 female/male ratio. Median age was 30 years and six patients were obese. Eleven patients had concomitant disease (diabetes in seven) and nine were using drugs. All had been studied for biochemical abnormalities and were asymptomatic. Ten patients had hepatomegaly and six splenomegaly. Ultrasound suggested the diagnosis in 50% of the cases. All had steatosis, inflammatory infiltrate, necrosis, fibrosis and Mallory bodies at different stages. One case had cirrhosis on initial biopsy and two developed cirrhosis on follow-up (one and eight years later). We did not find any correlation between clinical, biochemical or imaging characteristics and histological findings. When we compared these findings between obese and non obese patients and primary and secondary NASH we did not find any differences between groups. CONCLUSIONS. NASH is infrequent in our institution. The underlying pathogenesis seems to be multifactorial. There is no biochemical-histological correlation. Cirrhosis can develop in some cases.

AB - AIM. To describe the characteristics of non-alcoholic steatohepatitis (NASH) at the Instituto Nacional de la Nutricion Salvador Zubiran. MATERIAL AND METHODS. We reviewed all liver biopsy reports from January 1982 to December 1991. From patient records we obtained the following data: clinical, biochemical, imaging studies and we reviewed the histological material. We correlated clinical, biochemical and histological data. RESULTS. From 2963 biopsies reviewed we obtained 16 cases of NASH. We found a 7:1 female/male ratio. Median age was 30 years and six patients were obese. Eleven patients had concomitant disease (diabetes in seven) and nine were using drugs. All had been studied for biochemical abnormalities and were asymptomatic. Ten patients had hepatomegaly and six splenomegaly. Ultrasound suggested the diagnosis in 50% of the cases. All had steatosis, inflammatory infiltrate, necrosis, fibrosis and Mallory bodies at different stages. One case had cirrhosis on initial biopsy and two developed cirrhosis on follow-up (one and eight years later). We did not find any correlation between clinical, biochemical or imaging characteristics and histological findings. When we compared these findings between obese and non obese patients and primary and secondary NASH we did not find any differences between groups. CONCLUSIONS. NASH is infrequent in our institution. The underlying pathogenesis seems to be multifactorial. There is no biochemical-histological correlation. Cirrhosis can develop in some cases.

UR - http://www.scopus.com/inward/record.url?scp=0028394383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028394383&partnerID=8YFLogxK

M3 - Review article

VL - 46

SP - 85

EP - 92

JO - Revista de Investigacion Clinica

JF - Revista de Investigacion Clinica

SN - 0034-8376

IS - 2

ER -