Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children

Massimiliano Cantinotti, Raffaele Giordano, Marco Scalese, Bruno Murzi, Nadia Assanta, Isabella Spadoni, Maura Crocetti, Marco Marotta, Sabrina Molinaro, Shelby Kutty, Giorgio Iervasi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Pediatric echocardiographic nomograms for systolic/diastolic functional indices are limited by small sample size and inconsistent methodologies. Our aim was to establish pediatric nomograms for mitral valve (MV) pulsed wave Doppler (PWD) and tissue Doppler imaging (TDI) velocities. Methods We performed PWD/TDI measurements of MV velocities and generated models testing for linear/logarithmic/exponential/square root relationships. Heteroscedasticity was accounted for by White test or Breusch-Pagan test. Age, weight, height, heart rate (HR), and body surface area (BSA) were used as independent variables in different analyses to predict the mean values of each measurement. Results In all, 904 Caucasian Italian healthy children (age 0 days–17 years; 45.5% females; BSA 0.12–2.12 m2) were prospectively studied. No individual variable provided equations with an acceptable coefficient of determination (R2) and even the inclusion of multiple variables in the model resulted in only a partial amelioration of the R2. Higher R2 were obtained for PWD-E deceleration time (0.53), septal (Se′) and lateral (Le′) MV-TDI e′ velocity (Se′: 0.54; Le′: 0.55). Variability was higher at lower age and BSA. In older children patterns were more reproducible; however, the exclusion of neonates did not substantially improve the final models. The low R2 hampered building of z-scores and calculation of estimated percentiles. Thus normative data have been presented as observed percentile according to age for all measurements. Conclusions We report normal ranges for PWD and TDI mitral velocities derived from a large population of Caucasian children. Variability of diastolic patterns especially at lower ages needs to be taken into account.

Original languageEnglish (US)
Pages (from-to)288-299
Number of pages12
JournalJournal of Cardiology
Volume68
Issue number4
DOIs
StatePublished - Oct 1 2016

Fingerprint

Nomograms
Body Surface Area
Mitral Valve
Pediatrics
Deceleration
Sample Size
Linear Models
Reference Values
Heart Rate
Newborn Infant
Weights and Measures
Population

Keywords

  • Children
  • Echocardiography
  • Nomograms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cantinotti, M., Giordano, R., Scalese, M., Murzi, B., Assanta, N., Spadoni, I., ... Iervasi, G. (2016). Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children. Journal of Cardiology, 68(4), 288-299. https://doi.org/10.1016/j.jjcc.2015.10.004

Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children. / Cantinotti, Massimiliano; Giordano, Raffaele; Scalese, Marco; Murzi, Bruno; Assanta, Nadia; Spadoni, Isabella; Crocetti, Maura; Marotta, Marco; Molinaro, Sabrina; Kutty, Shelby; Iervasi, Giorgio.

In: Journal of Cardiology, Vol. 68, No. 4, 01.10.2016, p. 288-299.

Research output: Contribution to journalArticle

Cantinotti, M, Giordano, R, Scalese, M, Murzi, B, Assanta, N, Spadoni, I, Crocetti, M, Marotta, M, Molinaro, S, Kutty, S & Iervasi, G 2016, 'Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children', Journal of Cardiology, vol. 68, no. 4, pp. 288-299. https://doi.org/10.1016/j.jjcc.2015.10.004
Cantinotti M, Giordano R, Scalese M, Murzi B, Assanta N, Spadoni I et al. Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children. Journal of Cardiology. 2016 Oct 1;68(4):288-299. https://doi.org/10.1016/j.jjcc.2015.10.004
Cantinotti, Massimiliano ; Giordano, Raffaele ; Scalese, Marco ; Murzi, Bruno ; Assanta, Nadia ; Spadoni, Isabella ; Crocetti, Maura ; Marotta, Marco ; Molinaro, Sabrina ; Kutty, Shelby ; Iervasi, Giorgio. / Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children. In: Journal of Cardiology. 2016 ; Vol. 68, No. 4. pp. 288-299.
@article{e18451cfd56a4ad398e363b4ec9bf77b,
title = "Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children",
abstract = "Background Pediatric echocardiographic nomograms for systolic/diastolic functional indices are limited by small sample size and inconsistent methodologies. Our aim was to establish pediatric nomograms for mitral valve (MV) pulsed wave Doppler (PWD) and tissue Doppler imaging (TDI) velocities. Methods We performed PWD/TDI measurements of MV velocities and generated models testing for linear/logarithmic/exponential/square root relationships. Heteroscedasticity was accounted for by White test or Breusch-Pagan test. Age, weight, height, heart rate (HR), and body surface area (BSA) were used as independent variables in different analyses to predict the mean values of each measurement. Results In all, 904 Caucasian Italian healthy children (age 0 days–17 years; 45.5{\%} females; BSA 0.12–2.12 m2) were prospectively studied. No individual variable provided equations with an acceptable coefficient of determination (R2) and even the inclusion of multiple variables in the model resulted in only a partial amelioration of the R2. Higher R2 were obtained for PWD-E deceleration time (0.53), septal (Se′) and lateral (Le′) MV-TDI e′ velocity (Se′: 0.54; Le′: 0.55). Variability was higher at lower age and BSA. In older children patterns were more reproducible; however, the exclusion of neonates did not substantially improve the final models. The low R2 hampered building of z-scores and calculation of estimated percentiles. Thus normative data have been presented as observed percentile according to age for all measurements. Conclusions We report normal ranges for PWD and TDI mitral velocities derived from a large population of Caucasian children. Variability of diastolic patterns especially at lower ages needs to be taken into account.",
keywords = "Children, Echocardiography, Nomograms",
author = "Massimiliano Cantinotti and Raffaele Giordano and Marco Scalese and Bruno Murzi and Nadia Assanta and Isabella Spadoni and Maura Crocetti and Marco Marotta and Sabrina Molinaro and Shelby Kutty and Giorgio Iervasi",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.jjcc.2015.10.004",
language = "English (US)",
volume = "68",
pages = "288--299",
journal = "Journal of cardiography. Supplement",
issn = "0914-5087",
publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",
number = "4",

}

TY - JOUR

T1 - Nomograms for mitral inflow Doppler and tissue Doppler velocities in Caucasian children

AU - Cantinotti, Massimiliano

AU - Giordano, Raffaele

AU - Scalese, Marco

AU - Murzi, Bruno

AU - Assanta, Nadia

AU - Spadoni, Isabella

AU - Crocetti, Maura

AU - Marotta, Marco

AU - Molinaro, Sabrina

AU - Kutty, Shelby

AU - Iervasi, Giorgio

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background Pediatric echocardiographic nomograms for systolic/diastolic functional indices are limited by small sample size and inconsistent methodologies. Our aim was to establish pediatric nomograms for mitral valve (MV) pulsed wave Doppler (PWD) and tissue Doppler imaging (TDI) velocities. Methods We performed PWD/TDI measurements of MV velocities and generated models testing for linear/logarithmic/exponential/square root relationships. Heteroscedasticity was accounted for by White test or Breusch-Pagan test. Age, weight, height, heart rate (HR), and body surface area (BSA) were used as independent variables in different analyses to predict the mean values of each measurement. Results In all, 904 Caucasian Italian healthy children (age 0 days–17 years; 45.5% females; BSA 0.12–2.12 m2) were prospectively studied. No individual variable provided equations with an acceptable coefficient of determination (R2) and even the inclusion of multiple variables in the model resulted in only a partial amelioration of the R2. Higher R2 were obtained for PWD-E deceleration time (0.53), septal (Se′) and lateral (Le′) MV-TDI e′ velocity (Se′: 0.54; Le′: 0.55). Variability was higher at lower age and BSA. In older children patterns were more reproducible; however, the exclusion of neonates did not substantially improve the final models. The low R2 hampered building of z-scores and calculation of estimated percentiles. Thus normative data have been presented as observed percentile according to age for all measurements. Conclusions We report normal ranges for PWD and TDI mitral velocities derived from a large population of Caucasian children. Variability of diastolic patterns especially at lower ages needs to be taken into account.

AB - Background Pediatric echocardiographic nomograms for systolic/diastolic functional indices are limited by small sample size and inconsistent methodologies. Our aim was to establish pediatric nomograms for mitral valve (MV) pulsed wave Doppler (PWD) and tissue Doppler imaging (TDI) velocities. Methods We performed PWD/TDI measurements of MV velocities and generated models testing for linear/logarithmic/exponential/square root relationships. Heteroscedasticity was accounted for by White test or Breusch-Pagan test. Age, weight, height, heart rate (HR), and body surface area (BSA) were used as independent variables in different analyses to predict the mean values of each measurement. Results In all, 904 Caucasian Italian healthy children (age 0 days–17 years; 45.5% females; BSA 0.12–2.12 m2) were prospectively studied. No individual variable provided equations with an acceptable coefficient of determination (R2) and even the inclusion of multiple variables in the model resulted in only a partial amelioration of the R2. Higher R2 were obtained for PWD-E deceleration time (0.53), septal (Se′) and lateral (Le′) MV-TDI e′ velocity (Se′: 0.54; Le′: 0.55). Variability was higher at lower age and BSA. In older children patterns were more reproducible; however, the exclusion of neonates did not substantially improve the final models. The low R2 hampered building of z-scores and calculation of estimated percentiles. Thus normative data have been presented as observed percentile according to age for all measurements. Conclusions We report normal ranges for PWD and TDI mitral velocities derived from a large population of Caucasian children. Variability of diastolic patterns especially at lower ages needs to be taken into account.

KW - Children

KW - Echocardiography

KW - Nomograms

UR - http://www.scopus.com/inward/record.url?scp=84964489755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964489755&partnerID=8YFLogxK

U2 - 10.1016/j.jjcc.2015.10.004

DO - 10.1016/j.jjcc.2015.10.004

M3 - Article

VL - 68

SP - 288

EP - 299

JO - Journal of cardiography. Supplement

JF - Journal of cardiography. Supplement

SN - 0914-5087

IS - 4

ER -