Abstract
Endovascular stenting has matured into a commonly used treatment for peripheral arterial disease (PAD) due to its minimally invasive nature and associated reductions in short-term morbidity and mortality. The mechanical properties of the superelastic Nitinol alloy have played a major role in the explosion of peripheral artery stenting, with modern stents demonstrating reasonable resilience and durability. Yet in the superficial femoral and popliteal arteries, even the newest generation Nitinol stents continue to demonstrate clinical outcomes that leave significant room for improvement. Restenosis and progression of native arterial disease often lead to recurrence of symptoms and reinterventions that increase morbidity and health care expenditures. One of the main factors thought to be associated with stent failure in the femoropopliteal artery (FPA) is the unique and highly dynamic mechanical environment of the lower limb. Clinical and experimental data demonstrate that the FPA undergoes significant deformations with limb flexion. It is hypothesized that the inability of many existing stent designs to conform to these deformations likely plays a role in reconstruction failure, as repetitive movements of the leg and thigh combine with mechanical mismatch between the artery and the stent and result in mechanical damage to both the artery and the stent. In this review we will identify challenges and provide a mechanical perspective of FPA stenting, and then discuss current research directions with promise to provide a better understanding of Nitinol, specific features of stent design, and improved characterization of the biomechanical environment of the FPA to facilitate development of better stents for patients with PAD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 684-704 |
| Number of pages | 21 |
| Journal | Annals of biomedical engineering |
| Volume | 46 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2018 |
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Keywords
- Design
- Femoropopliteal artery
- Nitinol
- Peripheral arterial disease
- Stent
ASJC Scopus subject areas
- Biomedical Engineering
Cite this
Nitinol Stents in the Femoropopliteal Artery : A Mechanical Perspective on Material, Design, and Performance. / Maleckis, Kaspars; Anttila, Eric; Aylward, Paul; Poulson, William; Desyatova, Anastasia; Mactaggart, Jason N; Kamenskiy, Alexey.
In: Annals of biomedical engineering, Vol. 46, No. 5, 01.05.2018, p. 684-704.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nitinol Stents in the Femoropopliteal Artery
T2 - A Mechanical Perspective on Material, Design, and Performance
AU - Maleckis, Kaspars
AU - Anttila, Eric
AU - Aylward, Paul
AU - Poulson, William
AU - Desyatova, Anastasia
AU - Mactaggart, Jason N
AU - Kamenskiy, Alexey
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Endovascular stenting has matured into a commonly used treatment for peripheral arterial disease (PAD) due to its minimally invasive nature and associated reductions in short-term morbidity and mortality. The mechanical properties of the superelastic Nitinol alloy have played a major role in the explosion of peripheral artery stenting, with modern stents demonstrating reasonable resilience and durability. Yet in the superficial femoral and popliteal arteries, even the newest generation Nitinol stents continue to demonstrate clinical outcomes that leave significant room for improvement. Restenosis and progression of native arterial disease often lead to recurrence of symptoms and reinterventions that increase morbidity and health care expenditures. One of the main factors thought to be associated with stent failure in the femoropopliteal artery (FPA) is the unique and highly dynamic mechanical environment of the lower limb. Clinical and experimental data demonstrate that the FPA undergoes significant deformations with limb flexion. It is hypothesized that the inability of many existing stent designs to conform to these deformations likely plays a role in reconstruction failure, as repetitive movements of the leg and thigh combine with mechanical mismatch between the artery and the stent and result in mechanical damage to both the artery and the stent. In this review we will identify challenges and provide a mechanical perspective of FPA stenting, and then discuss current research directions with promise to provide a better understanding of Nitinol, specific features of stent design, and improved characterization of the biomechanical environment of the FPA to facilitate development of better stents for patients with PAD.
AB - Endovascular stenting has matured into a commonly used treatment for peripheral arterial disease (PAD) due to its minimally invasive nature and associated reductions in short-term morbidity and mortality. The mechanical properties of the superelastic Nitinol alloy have played a major role in the explosion of peripheral artery stenting, with modern stents demonstrating reasonable resilience and durability. Yet in the superficial femoral and popliteal arteries, even the newest generation Nitinol stents continue to demonstrate clinical outcomes that leave significant room for improvement. Restenosis and progression of native arterial disease often lead to recurrence of symptoms and reinterventions that increase morbidity and health care expenditures. One of the main factors thought to be associated with stent failure in the femoropopliteal artery (FPA) is the unique and highly dynamic mechanical environment of the lower limb. Clinical and experimental data demonstrate that the FPA undergoes significant deformations with limb flexion. It is hypothesized that the inability of many existing stent designs to conform to these deformations likely plays a role in reconstruction failure, as repetitive movements of the leg and thigh combine with mechanical mismatch between the artery and the stent and result in mechanical damage to both the artery and the stent. In this review we will identify challenges and provide a mechanical perspective of FPA stenting, and then discuss current research directions with promise to provide a better understanding of Nitinol, specific features of stent design, and improved characterization of the biomechanical environment of the FPA to facilitate development of better stents for patients with PAD.
KW - Design
KW - Femoropopliteal artery
KW - Nitinol
KW - Peripheral arterial disease
KW - Stent
UR - http://www.scopus.com/inward/record.url?scp=85042377055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042377055&partnerID=8YFLogxK
U2 - 10.1007/s10439-018-1990-1
DO - 10.1007/s10439-018-1990-1
M3 - Review article
C2 - 29470746
AN - SCOPUS:85042377055
VL - 46
SP - 684
EP - 704
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
SN - 0090-6964
IS - 5
ER -