Nicotinic acetylcholine receptors in mammalian brain

Barbara J Morley, Glenn R. Farley, Eric Javel

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Progress in understanding the CNS nicotinic acetylcholine receptor (nAChR) has been hindered by the absence of an antagonist that both biochemically binds receptor sites and blocks physiological activity. In contrast with the mammalian muscle nAChR, there is an apparent dissociation between the in vitro and in vivo behavior of CNS cholinergic antagonists. The biochemistry, pharmacology and physiology of brain nAChRs are discussed here. It is suggested that some of the discrepancies among these approaches can be reconciled by proposing multiple binding sites for cholinergic agents.

Original languageEnglish (US)
Pages (from-to)225-227
Number of pages3
JournalTrends in Pharmacological Sciences
Volume4
Issue numberC
DOIs
StatePublished - 1983

Fingerprint

Nicotinic Receptors
Brain
Biochemistry
Physiology
Cholinergic Antagonists
Cholinergic Agents
Muscle
Binding Sites
Pharmacology
Muscles
In Vitro Techniques

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Nicotinic acetylcholine receptors in mammalian brain. / Morley, Barbara J; Farley, Glenn R.; Javel, Eric.

In: Trends in Pharmacological Sciences, Vol. 4, No. C, 1983, p. 225-227.

Research output: Contribution to journalReview article

Morley, Barbara J ; Farley, Glenn R. ; Javel, Eric. / Nicotinic acetylcholine receptors in mammalian brain. In: Trends in Pharmacological Sciences. 1983 ; Vol. 4, No. C. pp. 225-227.
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