Nicotine enhances interleukin production of rat splenic t lymphocytes

Thomas M Petro, David S. Peterson, Yiu K. Fung

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Very little is known regarding the effects of nicotine, the most pharmacologically active component of tobacco products, on T lymphocyte activity or interleukin production. Therefore, rats were implanted subcutaneously with osmotic mini-pumps containing either physiological saline, nicotine (1.5 mg/kg/day) or a high dose of nicotine (4.5 mg/kg/day) for a period of 14 days. The ability of the splenic T lymphocytes to respond to the polyclonal T lymphocyte mitogens, Concanavalin A (ConA) or phytohemagglutinin (PHA), and the ability of mitogen stimulated splenic T lymphocytes to produce interleukin 2 (IL2) were determined. Treatment with nicotine suppressed, in a dose dependent fashion, the ability of splenic T lymphocytes to respond to mitogen, but dramatically enhanced the ability of mitogen stimulated lymphocytes to generate IL2.

Original languageEnglish (US)
Pages (from-to)463-475
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Volume14
Issue number3
DOIs
StatePublished - Jan 1 1992

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T-cells
Lymphocytes
Interleukins
Nicotine
Rats
Mitogens
T-Lymphocytes
Interleukin-2
Phytohemagglutinins
Concanavalin A
Tobacco Products
Pumps

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

Cite this

Nicotine enhances interleukin production of rat splenic t lymphocytes. / Petro, Thomas M; Peterson, David S.; Fung, Yiu K.

In: Immunopharmacology and Immunotoxicology, Vol. 14, No. 3, 01.01.1992, p. 463-475.

Research output: Contribution to journalArticle

Petro, Thomas M ; Peterson, David S. ; Fung, Yiu K. / Nicotine enhances interleukin production of rat splenic t lymphocytes. In: Immunopharmacology and Immunotoxicology. 1992 ; Vol. 14, No. 3. pp. 463-475.
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