Nicotine absorption after pulmonary instillation

David R. Herrmann, Keith M. Olsen, F. Charles Hiller

Research output: Contribution to journalArticle

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Abstract

Levels of nicotine in plasma were determined by gas chromatography in eight mongrel dogs after instillation of 0.5 mg of nicotine in 100 μL of normal saline at three levels of the tracheobronchial tree: the trachea, a subsegmental bronchus of the right middle lobe, and a subpleural location of the right middle lobe (“distal”). An equivalent dose was given intravenously (iv). Peak of nicotine concentrations in plasma were significantly lower after instillation at the trachea (11.5 ± 4.4 ng/mL) and the subsegmental bronchus (18.2 ± 5.0 ng/mL) than after an iv dose (30.3 ± 10.7 ng/mL); p < 0.05 for each comparison. In addition, the peak concentration after instillation at the trachea was significantly lower than that after instillation at the distal site (22.1 ± 6.2 ng/mL, p < 0.05). Time to peak concentration was significantly longer after tracheal instillation (5.3 ± 3.0 min) than after subsegmental instillation (2.0 ± 0.0 min) or iv infusion (2.0 ± 0.0 min); p < 0.05 for each comparison. Total drug absorbed, half‐life, and clearance were equivalent from all four sites. This study demonstrated that quantitative absorption of nicotine from the described lung sites is equivalent to that after an iv dose, with slower absorption and lower peak concentrations from the tracheal site.

Original languageEnglish (US)
Pages (from-to)1055-1058
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume81
Issue number11
DOIs
StatePublished - Nov 1992

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Nicotine
Trachea
Bronchi
Gas Chromatography
Half-Life
Dogs
Lung
Respiratory Tract Absorption
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Nicotine absorption after pulmonary instillation. / Herrmann, David R.; Olsen, Keith M.; Hiller, F. Charles.

In: Journal of Pharmaceutical Sciences, Vol. 81, No. 11, 11.1992, p. 1055-1058.

Research output: Contribution to journalArticle

Herrmann, DR, Olsen, KM & Hiller, FC 1992, 'Nicotine absorption after pulmonary instillation', Journal of Pharmaceutical Sciences, vol. 81, no. 11, pp. 1055-1058. https://doi.org/10.1002/jps.2600811102
Herrmann, David R. ; Olsen, Keith M. ; Hiller, F. Charles. / Nicotine absorption after pulmonary instillation. In: Journal of Pharmaceutical Sciences. 1992 ; Vol. 81, No. 11. pp. 1055-1058.
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