Nicotinamide and selenium stimulate the repair of DNA damage produced by N-nitrosobis (2-oxopropyl) amine

T. Lawson

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The effects of nicotinamide (NIC) and selenium (SE), given alone or together, on N-nitrosobis (2-oxopropyl) amine (BOP) - induced DNA damaged were measured in rat liver and colon. SE stimulated DNA repair in both tissues, whereas NIC was without effect. The failure of NIC to stimulate the repair of BOP - induced DNA damage in rat liver, where BOP is a methylating and hydroxypropylating agent, suggested that the nature of the DNA damaging agent could be important. NIC stimulated the repair of DNA damage induced by BOP (methylating agent in the pancreas) and N-nitrosodiethylamine (ethylating agent) but not by azaserine (carboxymethylating agent) or N-nitroso-5,6-dihydrouracil (carboxyethylating agent).

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalAnticancer Research
Issue number2
Publication statusPublished - Jan 1 1989


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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