Next generation analytic tools for large scale genetic epidemiology studies of complex diseases

Leah E. Mechanic, Huann Sheng Chen, Christopher I. Amos, Nilanjan Chatterjee, Nancy J. Cox, Rao L. Divi, Ruzong Fan, Emily L. Harris, Kevin Jacobs, Peter Kraft, Suzanne M. Leal, Kimberly McAllister, Jason H. Moore, Dina N. Paltoo, Michael A. Province, Erin M. Ramos, Marylyn D. Ritchie, Kathryn Roeder, Daniel J. Schaid, Matthew Stephens & 7 others Duncan C. Thomas, Clarice R. Weinberg, John S. Witte, Shunpu Zhang, Sebastian Zöllner, Eric J. Feuer, Elizabeth M. Gillanders

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Over the past several years, genome-wide association studies (GWAS) have succeeded in identifying hundreds of genetic markers associated with common diseases. However, most of these markers confer relatively small increments of risk and explain only a small proportion of familial clustering. To identify obstacles to future progress in genetic epidemiology research and provide recommendations to NIH for overcoming these barriers, the National Cancer Institute sponsored a workshop entitled "Next Generation Analytic Tools for Large-Scale Genetic Epidemiology Studies of Complex Diseases" on September 15-16, 2010. The goal of the workshop was to facilitate discussions on (1) statistical strategies and methods to efficiently identify genetic and environmental factors contributing to the risk of complex disease; and (2) how to develop, apply, and evaluate these strategies for the design, analysis, and interpretation of large-scale complex disease association studies in order to guide NIH in setting the future agenda in this area of research. The workshop was organized as a series of short presentations covering scientific (gene-gene and gene-environment interaction, complex phenotypes, and rare variants and next generation sequencing) and methodological (simulation modeling and computational resources and data management) topic areas. Specific needs to advance the field were identified during each session and are summarized.

Original languageEnglish (US)
Pages (from-to)22-35
Number of pages14
JournalGenetic Epidemiology
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Molecular Epidemiology
Education
Gene-Environment Interaction
Genetic Research
National Cancer Institute (U.S.)
Genome-Wide Association Study
Genetic Markers
Genes
Cluster Analysis
Phenotype
Research

Keywords

  • Complex phenotypes
  • Computational resources
  • Gene-environment interactions
  • Gene-gene interactions
  • Next generation sequencing
  • Rare variants
  • Simulations

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Mechanic, L. E., Chen, H. S., Amos, C. I., Chatterjee, N., Cox, N. J., Divi, R. L., ... Gillanders, E. M. (2012). Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genetic Epidemiology, 36(1), 22-35. https://doi.org/10.1002/gepi.20652

Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. / Mechanic, Leah E.; Chen, Huann Sheng; Amos, Christopher I.; Chatterjee, Nilanjan; Cox, Nancy J.; Divi, Rao L.; Fan, Ruzong; Harris, Emily L.; Jacobs, Kevin; Kraft, Peter; Leal, Suzanne M.; McAllister, Kimberly; Moore, Jason H.; Paltoo, Dina N.; Province, Michael A.; Ramos, Erin M.; Ritchie, Marylyn D.; Roeder, Kathryn; Schaid, Daniel J.; Stephens, Matthew; Thomas, Duncan C.; Weinberg, Clarice R.; Witte, John S.; Zhang, Shunpu; Zöllner, Sebastian; Feuer, Eric J.; Gillanders, Elizabeth M.

In: Genetic Epidemiology, Vol. 36, No. 1, 01.01.2012, p. 22-35.

Research output: Contribution to journalArticle

Mechanic, LE, Chen, HS, Amos, CI, Chatterjee, N, Cox, NJ, Divi, RL, Fan, R, Harris, EL, Jacobs, K, Kraft, P, Leal, SM, McAllister, K, Moore, JH, Paltoo, DN, Province, MA, Ramos, EM, Ritchie, MD, Roeder, K, Schaid, DJ, Stephens, M, Thomas, DC, Weinberg, CR, Witte, JS, Zhang, S, Zöllner, S, Feuer, EJ & Gillanders, EM 2012, 'Next generation analytic tools for large scale genetic epidemiology studies of complex diseases', Genetic Epidemiology, vol. 36, no. 1, pp. 22-35. https://doi.org/10.1002/gepi.20652
Mechanic, Leah E. ; Chen, Huann Sheng ; Amos, Christopher I. ; Chatterjee, Nilanjan ; Cox, Nancy J. ; Divi, Rao L. ; Fan, Ruzong ; Harris, Emily L. ; Jacobs, Kevin ; Kraft, Peter ; Leal, Suzanne M. ; McAllister, Kimberly ; Moore, Jason H. ; Paltoo, Dina N. ; Province, Michael A. ; Ramos, Erin M. ; Ritchie, Marylyn D. ; Roeder, Kathryn ; Schaid, Daniel J. ; Stephens, Matthew ; Thomas, Duncan C. ; Weinberg, Clarice R. ; Witte, John S. ; Zhang, Shunpu ; Zöllner, Sebastian ; Feuer, Eric J. ; Gillanders, Elizabeth M. / Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. In: Genetic Epidemiology. 2012 ; Vol. 36, No. 1. pp. 22-35.
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