New use of BCG for recombinant vaccines

C. K. Stover, V. F. De La Cruz, T. R. Fuerst, J. E. Burlein, L. A. Benson, L. T. Bennett, G. P. Bansal, J. F. Young, M. H. Lee, G. F. Hatfull, S. B. Snapper, R. G. Barletta, W. R. Jacobs, B. R. Bloom

Research output: Contribution to journalArticle

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Abstract

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalNature
Volume351
Issue number6326
DOIs
StatePublished - Jan 1 1991

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BCG Vaccine
Synthetic Vaccines
Mycobacterium bovis
Antigens
Vaccines
Humoral Immunity
Heat-Shock Proteins
Cellular Immunity
Bacillus

ASJC Scopus subject areas

  • General

Cite this

Stover, C. K., De La Cruz, V. F., Fuerst, T. R., Burlein, J. E., Benson, L. A., Bennett, L. T., ... Bloom, B. R. (1991). New use of BCG for recombinant vaccines. Nature, 351(6326), 456-460. https://doi.org/10.1038/351456a0

New use of BCG for recombinant vaccines. / Stover, C. K.; De La Cruz, V. F.; Fuerst, T. R.; Burlein, J. E.; Benson, L. A.; Bennett, L. T.; Bansal, G. P.; Young, J. F.; Lee, M. H.; Hatfull, G. F.; Snapper, S. B.; Barletta, R. G.; Jacobs, W. R.; Bloom, B. R.

In: Nature, Vol. 351, No. 6326, 01.01.1991, p. 456-460.

Research output: Contribution to journalArticle

Stover, CK, De La Cruz, VF, Fuerst, TR, Burlein, JE, Benson, LA, Bennett, LT, Bansal, GP, Young, JF, Lee, MH, Hatfull, GF, Snapper, SB, Barletta, RG, Jacobs, WR & Bloom, BR 1991, 'New use of BCG for recombinant vaccines', Nature, vol. 351, no. 6326, pp. 456-460. https://doi.org/10.1038/351456a0
Stover CK, De La Cruz VF, Fuerst TR, Burlein JE, Benson LA, Bennett LT et al. New use of BCG for recombinant vaccines. Nature. 1991 Jan 1;351(6326):456-460. https://doi.org/10.1038/351456a0
Stover, C. K. ; De La Cruz, V. F. ; Fuerst, T. R. ; Burlein, J. E. ; Benson, L. A. ; Bennett, L. T. ; Bansal, G. P. ; Young, J. F. ; Lee, M. H. ; Hatfull, G. F. ; Snapper, S. B. ; Barletta, R. G. ; Jacobs, W. R. ; Bloom, B. R. / New use of BCG for recombinant vaccines. In: Nature. 1991 ; Vol. 351, No. 6326. pp. 456-460.
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