New nanoscale pulsatile drug delivery system

Xinming Liu, Bin Yang, Yu Lu Wang, Jin Ye Wang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A new type of photocontrolled, liposomal drug delivery system with a average diameter of 99.7 nm that can achieve zero-order, multi-pulsatile release, and sustained release was described. The cytotoxicity of this drag delivery system was examined using NIH3T3 cells. The synthetic phototrigger decreases the spontaneous release of drug and increases the stability of liposomes beyond what have been previously reported. The amount of drug released from liposomes can be controlled by maintaining the concentration of the cis isomer of AB lipid 1 by UV irradiation, and the release rate can be controlled by altering the incorporation ratio of AB lipid 1.

Original languageEnglish (US)
Pages (from-to)2792-2795
Number of pages4
JournalChemistry of Materials
Volume17
Issue number11
DOIs
StatePublished - May 31 2005

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Liposomes
Lipids
Cytotoxicity
Isomers
Pharmaceutical Preparations
Drag
Irradiation
Drug Delivery Systems

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

Liu, X., Yang, B., Wang, Y. L., & Wang, J. Y. (2005). New nanoscale pulsatile drug delivery system. Chemistry of Materials, 17(11), 2792-2795. https://doi.org/10.1021/cm0479335

New nanoscale pulsatile drug delivery system. / Liu, Xinming; Yang, Bin; Wang, Yu Lu; Wang, Jin Ye.

In: Chemistry of Materials, Vol. 17, No. 11, 31.05.2005, p. 2792-2795.

Research output: Contribution to journalArticle

Liu, X, Yang, B, Wang, YL & Wang, JY 2005, 'New nanoscale pulsatile drug delivery system', Chemistry of Materials, vol. 17, no. 11, pp. 2792-2795. https://doi.org/10.1021/cm0479335
Liu X, Yang B, Wang YL, Wang JY. New nanoscale pulsatile drug delivery system. Chemistry of Materials. 2005 May 31;17(11):2792-2795. https://doi.org/10.1021/cm0479335
Liu, Xinming ; Yang, Bin ; Wang, Yu Lu ; Wang, Jin Ye. / New nanoscale pulsatile drug delivery system. In: Chemistry of Materials. 2005 ; Vol. 17, No. 11. pp. 2792-2795.
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