New and emerging therapies for short bowel syndrome in children

Jon A. Vanderhoof, Rosemary J. Young, Jon S Thompson

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

This review provides an overview of traditional as well as emerging therapies useful in the management of pediatric short bowel syndrome. Pediatric short bowel syndrome is relatively uncommon; however, when it does occur, it presents a unique challenge to medical care providers. The use of parenteral and enteral nutrition to maximize growth and enhance intestinal adaptation so as to increase absorptive surface area has been the primary focus of therapy. In recent years, the advent of pharmacologic advances, including the use of antibacterial drugs, anti-motility drugs and hormonal therapies, has had a significant impact on this condition. At times, surgery may be indicated for dealing with complications, or providing alternative therapy such as transplantation. With ongoing research, it is likely that improved pharmacologic therapy will be available for enhanced intestinal adaptation, control of gut motility, treatment of small bowel bacterial overgrowth, and treatment of rejection following small intestinal transplantation.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
JournalPediatric Drugs
Volume5
Issue number8
DOIs
StatePublished - Sep 8 2003

Fingerprint

Short Bowel Syndrome
Transplantation
Pediatrics
Therapeutics
Parenteral Nutrition
Enteral Nutrition
Complementary Therapies
Drug Therapy
Growth
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

Cite this

New and emerging therapies for short bowel syndrome in children. / Vanderhoof, Jon A.; Young, Rosemary J.; Thompson, Jon S.

In: Pediatric Drugs, Vol. 5, No. 8, 08.09.2003, p. 525-531.

Research output: Contribution to journalReview article

Vanderhoof, Jon A. ; Young, Rosemary J. ; Thompson, Jon S. / New and emerging therapies for short bowel syndrome in children. In: Pediatric Drugs. 2003 ; Vol. 5, No. 8. pp. 525-531.
@article{33b03f5b68264016abfcc33cb78055ca,
title = "New and emerging therapies for short bowel syndrome in children",
abstract = "This review provides an overview of traditional as well as emerging therapies useful in the management of pediatric short bowel syndrome. Pediatric short bowel syndrome is relatively uncommon; however, when it does occur, it presents a unique challenge to medical care providers. The use of parenteral and enteral nutrition to maximize growth and enhance intestinal adaptation so as to increase absorptive surface area has been the primary focus of therapy. In recent years, the advent of pharmacologic advances, including the use of antibacterial drugs, anti-motility drugs and hormonal therapies, has had a significant impact on this condition. At times, surgery may be indicated for dealing with complications, or providing alternative therapy such as transplantation. With ongoing research, it is likely that improved pharmacologic therapy will be available for enhanced intestinal adaptation, control of gut motility, treatment of small bowel bacterial overgrowth, and treatment of rejection following small intestinal transplantation.",
author = "Vanderhoof, {Jon A.} and Young, {Rosemary J.} and Thompson, {Jon S}",
year = "2003",
month = "9",
day = "8",
doi = "10.2165/00148581-200305080-00003",
language = "English (US)",
volume = "5",
pages = "525--531",
journal = "Paediatric Drugs",
issn = "1174-5878",
publisher = "Adis International Ltd",
number = "8",

}

TY - JOUR

T1 - New and emerging therapies for short bowel syndrome in children

AU - Vanderhoof, Jon A.

AU - Young, Rosemary J.

AU - Thompson, Jon S

PY - 2003/9/8

Y1 - 2003/9/8

N2 - This review provides an overview of traditional as well as emerging therapies useful in the management of pediatric short bowel syndrome. Pediatric short bowel syndrome is relatively uncommon; however, when it does occur, it presents a unique challenge to medical care providers. The use of parenteral and enteral nutrition to maximize growth and enhance intestinal adaptation so as to increase absorptive surface area has been the primary focus of therapy. In recent years, the advent of pharmacologic advances, including the use of antibacterial drugs, anti-motility drugs and hormonal therapies, has had a significant impact on this condition. At times, surgery may be indicated for dealing with complications, or providing alternative therapy such as transplantation. With ongoing research, it is likely that improved pharmacologic therapy will be available for enhanced intestinal adaptation, control of gut motility, treatment of small bowel bacterial overgrowth, and treatment of rejection following small intestinal transplantation.

AB - This review provides an overview of traditional as well as emerging therapies useful in the management of pediatric short bowel syndrome. Pediatric short bowel syndrome is relatively uncommon; however, when it does occur, it presents a unique challenge to medical care providers. The use of parenteral and enteral nutrition to maximize growth and enhance intestinal adaptation so as to increase absorptive surface area has been the primary focus of therapy. In recent years, the advent of pharmacologic advances, including the use of antibacterial drugs, anti-motility drugs and hormonal therapies, has had a significant impact on this condition. At times, surgery may be indicated for dealing with complications, or providing alternative therapy such as transplantation. With ongoing research, it is likely that improved pharmacologic therapy will be available for enhanced intestinal adaptation, control of gut motility, treatment of small bowel bacterial overgrowth, and treatment of rejection following small intestinal transplantation.

UR - http://www.scopus.com/inward/record.url?scp=0041823434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041823434&partnerID=8YFLogxK

U2 - 10.2165/00148581-200305080-00003

DO - 10.2165/00148581-200305080-00003

M3 - Review article

VL - 5

SP - 525

EP - 531

JO - Paediatric Drugs

JF - Paediatric Drugs

SN - 1174-5878

IS - 8

ER -