Neutrophils in the Tumor Microenvironment

Lingyun Wu, Sugandha Saxena, Rakesh K. Singh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neutrophils are the first responders to inflammation, infection, and injury. As one of the most abundant leukocytes in the immune system, neutrophils play an essential role in cancer progression, through multiple mechanisms, including promoting angiogenesis, immunosuppression, and cancer metastasis. Recent studies demonstrating elevated neutrophil to lymphocyte ratios suggest neutrophil as a potential therapeutic target and biomarker for disease status in cancer. This chapter will discuss the phenotypic and functional changes in the neutrophil in the tumor microenvironment, the underlying mechanism(s) of neutrophil facilitated cancer metastasis, and clinical potential of neutrophils as a prognostic/diagnostic marker and therapeutic target.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages1-20
Number of pages20
DOIs
StatePublished - Jan 1 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1224
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Angiogenesis
  • CXCR2 ligands
  • IL17
  • Metastasis
  • NETs
  • NLR
  • Neutrophil
  • Neutrophil-released proteases
  • Pro-tumor chemokines
  • Pro-tumor cytokines
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wu, L., Saxena, S., & Singh, R. K. (2020). Neutrophils in the Tumor Microenvironment. In Advances in Experimental Medicine and Biology (pp. 1-20). (Advances in Experimental Medicine and Biology; Vol. 1224). Springer. https://doi.org/10.1007/978-3-030-35723-8_1