Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy

Saba Khalilpour, Ghazaleh Behnammanesh, Fouad Suede, Mohammed O. Ezzat, Jayadhisan Muniandy, Yasser Tabana, Mohamed B.K. Ahamed, Ali Tamayol, Amin Malik Shah Majid, Enrico Sangiovanni, Mario Dell'Agli, Aman Shah Majid

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β-carotene were 6.79 ± 0.009 μg/mL, 10.94 ± 0.09 μg/mL, and 6.25 ± 0.06 μg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.

Original languageEnglish (US)
Article number48
JournalBiomedicines
Volume6
Issue number2
DOIs
StatePublished - Jun 1 2018

Fingerprint

Rhus
Ischemic Optic Neuropathy
Linoleic Acid
Optic Nerve Injuries
Nerve Crush
Optics
Anti-Inflammatory Agents
Ischemia
Cathepsins
Optic Nerve Diseases
Carotenoids
Nervous System
Inhibitory Concentration 50
Oxidative stress
Neurology
Oxidative Stress
Fluorescence
Tomography
Inflammation
Crush Injuries

Keywords

  • Anti-neuroinflammation
  • Ischemic optic neuropathy
  • Linoleic acid
  • Neuroprotection
  • Rhus coriaria

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Khalilpour, S., Behnammanesh, G., Suede, F., Ezzat, M. O., Muniandy, J., Tabana, Y., ... Majid, A. S. (2018). Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy. Biomedicines, 6(2), [48]. https://doi.org/10.3390/biomedicines6020048

Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy. / Khalilpour, Saba; Behnammanesh, Ghazaleh; Suede, Fouad; Ezzat, Mohammed O.; Muniandy, Jayadhisan; Tabana, Yasser; Ahamed, Mohamed B.K.; Tamayol, Ali; Majid, Amin Malik Shah; Sangiovanni, Enrico; Dell'Agli, Mario; Majid, Aman Shah.

In: Biomedicines, Vol. 6, No. 2, 48, 01.06.2018.

Research output: Contribution to journalArticle

Khalilpour, S, Behnammanesh, G, Suede, F, Ezzat, MO, Muniandy, J, Tabana, Y, Ahamed, MBK, Tamayol, A, Majid, AMS, Sangiovanni, E, Dell'Agli, M & Majid, AS 2018, 'Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy', Biomedicines, vol. 6, no. 2, 48. https://doi.org/10.3390/biomedicines6020048
Khalilpour, Saba ; Behnammanesh, Ghazaleh ; Suede, Fouad ; Ezzat, Mohammed O. ; Muniandy, Jayadhisan ; Tabana, Yasser ; Ahamed, Mohamed B.K. ; Tamayol, Ali ; Majid, Amin Malik Shah ; Sangiovanni, Enrico ; Dell'Agli, Mario ; Majid, Aman Shah. / Neuroprotective and anti-inflammatory effects of Rhus coriaria extract in a mouse model of ischemic optic neuropathy. In: Biomedicines. 2018 ; Vol. 6, No. 2.
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