Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity

Huanhuan Li, Yutong Liu, Xiaoqing Gao, Lifen Liu, Siyiti Amuti, Dandan Wu, Fen Jiang, Liang Huang, Geying Wang, Jiujiang Zeng, Bin Ma, Qionglan Yuan

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1 Scopus citations

Abstract

Neuroplastin 65 (Np65) is a brain-specific cell adhesion molecule that is highly expressed in the hippocampus, amygdala, and cortex, regions of the brain that are associated with memory and emotions. However, the role of Np65 in regulation of emotional behavior is still unclear. In the present study, we show that Np65 knock-out (Np65 KO) mice display enhanced anxiety-like behavior, a reduction in some aspects of depressive-like behaviors, and increased sociability and memory. Biochemical investigations revealed that Np65 KO mice show increased adult-born neurons and proliferation in the hippocampus. In addition, the level of 5-hydroxytryptamine (5-HT) in the hippocampus was reduced. The expression of tryptophan hydroxylase 2 in the brainstem and the expression of the 5-HT3A receptor were also decreased. Electrophysiological recordings confirmed an impaired maintenance of long-term potentiation in the hippocampus of Np65 KO mice. Together, our findings uncover a role for Np65 in regulating anxiety- and depressive-like behaviors and suggest that Np65 may be essential for the maintenance of emotional stability, indicating that it might be an attractive potential target for treatment of psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)3401-3415
Number of pages15
JournalFEBS Journal
Volume286
Issue number17
DOIs
StatePublished - Sep 1 2019

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Keywords

  • 5-hydroxytryptamine
  • anxiety
  • depression
  • neurogenesis
  • neuroplastin 65

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Li, H., Liu, Y., Gao, X., Liu, L., Amuti, S., Wu, D., Jiang, F., Huang, L., Wang, G., Zeng, J., Ma, B., & Yuan, Q. (2019). Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity. FEBS Journal, 286(17), 3401-3415. https://doi.org/10.1111/febs.14865