Neuropharmacology of the interoceptive stimulus properties of nicotine

Thomas E. Wooters, Rick A Bevins, Michael T. Bardo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Preclinical drug discrimination techniques play a significant role in advancing our knowledge of the receptor mechanisms underlying the interoceptive effects of nicotine. Early reports confirmed that nicotinic acetylcholine receptors (nAChRs) are critical for transduction of the nicotine cue. In recent years, advances in molecular biology and the discovery of novel ligands with greater selectively for specific nAChR subtypes have furthered our understanding of these mechanisms. There is now evidence regarding the specific nAChR subtypes involved in nicotine discrimination; in addition, there is also evidence suggesting that other systems (i.e., adenosine, cannabinoid, dopamine, glutamate and serotonin) may play a modulatory role. The neuroanatomical structures mediating the nicotine cue have also begun to be elucidated. However, much remains to be learned about the predictive validity of the drug discrimination procedure, particularly with regard to the relation between interoceptive and reinforcing effects and individual differences in vulnerability to tobacco dependence. Recent data also suggests that the mechanisms involved in the conditional and discriminative stimulus properties of nicotine may be dissociable. Avenues for future research should include assessing the mechanisms of the subjective effects of nicotine withdrawal, factors contributing to individual differences in sensitivity to the nicotine cue, and the role of behavioral factors involved in drug cross-substitution.

Original languageEnglish (US)
Pages (from-to)243-255
Number of pages13
JournalCurrent Drug Abuse Reviews
Volume2
Issue number3
DOIs
StatePublished - Nov 1 2009

Fingerprint

Neuropharmacology
Nicotine
Cues
Individuality
Drug Substitution
Tobacco Use Disorder
Cannabinoids
Nicotinic Receptors
Pharmaceutical Preparations
Adenosine
Molecular Biology
Glutamic Acid
Dopamine
Serotonin
Ligands

Keywords

  • Conditional stimulus
  • Drug discrimination
  • Nicotine
  • Nicotinic acetylcholine receptor

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Neuropharmacology of the interoceptive stimulus properties of nicotine. / Wooters, Thomas E.; Bevins, Rick A; Bardo, Michael T.

In: Current Drug Abuse Reviews, Vol. 2, No. 3, 01.11.2009, p. 243-255.

Research output: Contribution to journalArticle

Wooters, Thomas E. ; Bevins, Rick A ; Bardo, Michael T. / Neuropharmacology of the interoceptive stimulus properties of nicotine. In: Current Drug Abuse Reviews. 2009 ; Vol. 2, No. 3. pp. 243-255.
@article{cea6990361974aa2b4e5ca0ff30d1e59,
title = "Neuropharmacology of the interoceptive stimulus properties of nicotine",
abstract = "Preclinical drug discrimination techniques play a significant role in advancing our knowledge of the receptor mechanisms underlying the interoceptive effects of nicotine. Early reports confirmed that nicotinic acetylcholine receptors (nAChRs) are critical for transduction of the nicotine cue. In recent years, advances in molecular biology and the discovery of novel ligands with greater selectively for specific nAChR subtypes have furthered our understanding of these mechanisms. There is now evidence regarding the specific nAChR subtypes involved in nicotine discrimination; in addition, there is also evidence suggesting that other systems (i.e., adenosine, cannabinoid, dopamine, glutamate and serotonin) may play a modulatory role. The neuroanatomical structures mediating the nicotine cue have also begun to be elucidated. However, much remains to be learned about the predictive validity of the drug discrimination procedure, particularly with regard to the relation between interoceptive and reinforcing effects and individual differences in vulnerability to tobacco dependence. Recent data also suggests that the mechanisms involved in the conditional and discriminative stimulus properties of nicotine may be dissociable. Avenues for future research should include assessing the mechanisms of the subjective effects of nicotine withdrawal, factors contributing to individual differences in sensitivity to the nicotine cue, and the role of behavioral factors involved in drug cross-substitution.",
keywords = "Conditional stimulus, Drug discrimination, Nicotine, Nicotinic acetylcholine receptor",
author = "Wooters, {Thomas E.} and Bevins, {Rick A} and Bardo, {Michael T.}",
year = "2009",
month = "11",
day = "1",
doi = "10.2174/1874473710902030243",
language = "English (US)",
volume = "2",
pages = "243--255",
journal = "Current Drug Research Reviews",
issn = "2589-9775",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Neuropharmacology of the interoceptive stimulus properties of nicotine

AU - Wooters, Thomas E.

AU - Bevins, Rick A

AU - Bardo, Michael T.

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Preclinical drug discrimination techniques play a significant role in advancing our knowledge of the receptor mechanisms underlying the interoceptive effects of nicotine. Early reports confirmed that nicotinic acetylcholine receptors (nAChRs) are critical for transduction of the nicotine cue. In recent years, advances in molecular biology and the discovery of novel ligands with greater selectively for specific nAChR subtypes have furthered our understanding of these mechanisms. There is now evidence regarding the specific nAChR subtypes involved in nicotine discrimination; in addition, there is also evidence suggesting that other systems (i.e., adenosine, cannabinoid, dopamine, glutamate and serotonin) may play a modulatory role. The neuroanatomical structures mediating the nicotine cue have also begun to be elucidated. However, much remains to be learned about the predictive validity of the drug discrimination procedure, particularly with regard to the relation between interoceptive and reinforcing effects and individual differences in vulnerability to tobacco dependence. Recent data also suggests that the mechanisms involved in the conditional and discriminative stimulus properties of nicotine may be dissociable. Avenues for future research should include assessing the mechanisms of the subjective effects of nicotine withdrawal, factors contributing to individual differences in sensitivity to the nicotine cue, and the role of behavioral factors involved in drug cross-substitution.

AB - Preclinical drug discrimination techniques play a significant role in advancing our knowledge of the receptor mechanisms underlying the interoceptive effects of nicotine. Early reports confirmed that nicotinic acetylcholine receptors (nAChRs) are critical for transduction of the nicotine cue. In recent years, advances in molecular biology and the discovery of novel ligands with greater selectively for specific nAChR subtypes have furthered our understanding of these mechanisms. There is now evidence regarding the specific nAChR subtypes involved in nicotine discrimination; in addition, there is also evidence suggesting that other systems (i.e., adenosine, cannabinoid, dopamine, glutamate and serotonin) may play a modulatory role. The neuroanatomical structures mediating the nicotine cue have also begun to be elucidated. However, much remains to be learned about the predictive validity of the drug discrimination procedure, particularly with regard to the relation between interoceptive and reinforcing effects and individual differences in vulnerability to tobacco dependence. Recent data also suggests that the mechanisms involved in the conditional and discriminative stimulus properties of nicotine may be dissociable. Avenues for future research should include assessing the mechanisms of the subjective effects of nicotine withdrawal, factors contributing to individual differences in sensitivity to the nicotine cue, and the role of behavioral factors involved in drug cross-substitution.

KW - Conditional stimulus

KW - Drug discrimination

KW - Nicotine

KW - Nicotinic acetylcholine receptor

UR - http://www.scopus.com/inward/record.url?scp=77951542294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951542294&partnerID=8YFLogxK

U2 - 10.2174/1874473710902030243

DO - 10.2174/1874473710902030243

M3 - Article

C2 - 20443771

AN - SCOPUS:77951542294

VL - 2

SP - 243

EP - 255

JO - Current Drug Research Reviews

JF - Current Drug Research Reviews

SN - 2589-9775

IS - 3

ER -