Neuronal injury regulates fractalkine: Relevance for HIV-1 associated dementia

David Erichsen, Alicia L. Lopez, Hui Peng, Douglas F Niemann, Clancy Williams, Michael Bauer, Susan Morgello, Robin L. Cotter, Lisa A. Ryan, Anuja Ghorpade, Howard Eliot Gendelman, Jialin C Zheng

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Fractalkine (FKN), a chemokine highly expressed in the central nervous system, participates in inflammatory responses operative in many brain disorders including HIV-1 associated dementia (HAD). In this report, HIV-1 progeny virions and pro-inflammatory products led to FKN production associated with neuronal injury and apoptosis. FKN was produced by neurons and astrocytes; but differentially produced by the two cell types. Laboratory tests paralleled those in infected people where cerebrospinal fluid FKN levels in HIV-1 infected cognitively impaired (n=16) patients were found to be increased when compared to infected patients without cognitive impairment (n=8, P=0.0345). These results demonstrate a possible role of FKN in HAD pathogenesis.

Original languageEnglish (US)
Pages (from-to)144-155
Number of pages12
JournalJournal of Neuroimmunology
Volume138
Issue number1-2
DOIs
StatePublished - May 2003

Fingerprint

Chemokine CX3CL1
Dementia
HIV-1
Wounds and Injuries
Brain Diseases
Chemokines
Astrocytes
Virion
Cerebrospinal Fluid
Central Nervous System
Apoptosis
Neurons

Keywords

  • Chemokines
  • Fractalkine
  • HIV-1 associated dementia
  • Inflammation
  • Macrophage

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Neuronal injury regulates fractalkine : Relevance for HIV-1 associated dementia. / Erichsen, David; Lopez, Alicia L.; Peng, Hui; Niemann, Douglas F; Williams, Clancy; Bauer, Michael; Morgello, Susan; Cotter, Robin L.; Ryan, Lisa A.; Ghorpade, Anuja; Gendelman, Howard Eliot; Zheng, Jialin C.

In: Journal of Neuroimmunology, Vol. 138, No. 1-2, 05.2003, p. 144-155.

Research output: Contribution to journalArticle

Erichsen, D, Lopez, AL, Peng, H, Niemann, DF, Williams, C, Bauer, M, Morgello, S, Cotter, RL, Ryan, LA, Ghorpade, A, Gendelman, HE & Zheng, JC 2003, 'Neuronal injury regulates fractalkine: Relevance for HIV-1 associated dementia', Journal of Neuroimmunology, vol. 138, no. 1-2, pp. 144-155. https://doi.org/10.1016/S0165-5728(03)00117-6
Erichsen, David ; Lopez, Alicia L. ; Peng, Hui ; Niemann, Douglas F ; Williams, Clancy ; Bauer, Michael ; Morgello, Susan ; Cotter, Robin L. ; Ryan, Lisa A. ; Ghorpade, Anuja ; Gendelman, Howard Eliot ; Zheng, Jialin C. / Neuronal injury regulates fractalkine : Relevance for HIV-1 associated dementia. In: Journal of Neuroimmunology. 2003 ; Vol. 138, No. 1-2. pp. 144-155.
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