Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke

Carmen M. Cirstea, Randolph J. Nudo, Sorin C. Craciunas, Elena A. Popescu, In Young Choi, Phil Lee, Hung Wen Yeh, Cary R. Savage, William M. Brooks

Research output: Contribution to journalArticle

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Abstract

Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent with their involvement in post-stroke reorganization. Specifically, we expected that neuronal and glial compartments would be altered in radiologically normal-appearing, i.e., spared, PMd and SMA in patients with arm paresis. Twenty survivors of a single ischemic subcortical stroke and 16 age-matched healthy controls were included. At more than six months after stroke, metabolites related to neuronal and glial compartments: N-acetylaspartate, myo-inositol, and glutamate/glutamine, were quantified by proton magnetic resonance spectroscopy in PMd and SMA in both injured (ipsilesional) and un-injured (contralesional) hemispheres. Correlations between metabolites were also calculated. Finally, relationships between metabolite concentrations and arm motor impairment (total and proximal Fugl-Meyer Upper Extremity, FMUE, scores) were analyzed. Compared to controls, stroke survivors showed significantly higher ipsilesional PMd myo-inositol and lower SMA N-acetylaspartate. Significantly lower metabolite correlations were found between ipsilesional and contralesional SMA. Ipsilesional N-acetylaspartate was significantly related to proximal FMUE scores. This study provides evidence of abnormalities in metabolites, specific to neuronal and glial compartments, across spared non-primary motor areas. Ipsilesional alterations were related to proximal arm motor impairment. Our results suggest the involvement of these areas in post-stroke reorganization.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalBrain Research
Volume1463
DOIs
StatePublished - Jun 29 2012

Fingerprint

Motor Cortex
Neuroglia
Stroke
Arm
Inositol
Survivors
Paresis
Glutamine
Upper Extremity
Glutamic Acid
N-acetylaspartate

Keywords

  • H-MRS
  • Neuronal and glial compartments
  • Non-primary motor areas
  • Subcortical stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Cirstea, C. M., Nudo, R. J., Craciunas, S. C., Popescu, E. A., Choi, I. Y., Lee, P., ... Brooks, W. M. (2012). Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. Brain Research, 1463, 75-84. https://doi.org/10.1016/j.brainres.2012.04.052

Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. / Cirstea, Carmen M.; Nudo, Randolph J.; Craciunas, Sorin C.; Popescu, Elena A.; Choi, In Young; Lee, Phil; Yeh, Hung Wen; Savage, Cary R.; Brooks, William M.

In: Brain Research, Vol. 1463, 29.06.2012, p. 75-84.

Research output: Contribution to journalArticle

Cirstea, CM, Nudo, RJ, Craciunas, SC, Popescu, EA, Choi, IY, Lee, P, Yeh, HW, Savage, CR & Brooks, WM 2012, 'Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke', Brain Research, vol. 1463, pp. 75-84. https://doi.org/10.1016/j.brainres.2012.04.052
Cirstea CM, Nudo RJ, Craciunas SC, Popescu EA, Choi IY, Lee P et al. Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. Brain Research. 2012 Jun 29;1463:75-84. https://doi.org/10.1016/j.brainres.2012.04.052
Cirstea, Carmen M. ; Nudo, Randolph J. ; Craciunas, Sorin C. ; Popescu, Elena A. ; Choi, In Young ; Lee, Phil ; Yeh, Hung Wen ; Savage, Cary R. ; Brooks, William M. / Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. In: Brain Research. 2012 ; Vol. 1463. pp. 75-84.
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abstract = "Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent with their involvement in post-stroke reorganization. Specifically, we expected that neuronal and glial compartments would be altered in radiologically normal-appearing, i.e., spared, PMd and SMA in patients with arm paresis. Twenty survivors of a single ischemic subcortical stroke and 16 age-matched healthy controls were included. At more than six months after stroke, metabolites related to neuronal and glial compartments: N-acetylaspartate, myo-inositol, and glutamate/glutamine, were quantified by proton magnetic resonance spectroscopy in PMd and SMA in both injured (ipsilesional) and un-injured (contralesional) hemispheres. Correlations between metabolites were also calculated. Finally, relationships between metabolite concentrations and arm motor impairment (total and proximal Fugl-Meyer Upper Extremity, FMUE, scores) were analyzed. Compared to controls, stroke survivors showed significantly higher ipsilesional PMd myo-inositol and lower SMA N-acetylaspartate. Significantly lower metabolite correlations were found between ipsilesional and contralesional SMA. Ipsilesional N-acetylaspartate was significantly related to proximal FMUE scores. This study provides evidence of abnormalities in metabolites, specific to neuronal and glial compartments, across spared non-primary motor areas. Ipsilesional alterations were related to proximal arm motor impairment. Our results suggest the involvement of these areas in post-stroke reorganization.",
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