Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke

Carmen M. Cirstea, Randolph J. Nudo, Sorin C. Craciunas, Elena A. Popescu, In Young Choi, Phil Lee, Hung Wen Yeh, Cary R Savage, William M. Brooks

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent with their involvement in post-stroke reorganization. Specifically, we expected that neuronal and glial compartments would be altered in radiologically normal-appearing, i.e., spared, PMd and SMA in patients with arm paresis. Twenty survivors of a single ischemic subcortical stroke and 16 age-matched healthy controls were included. At more than six months after stroke, metabolites related to neuronal and glial compartments: N-acetylaspartate, myo-inositol, and glutamate/glutamine, were quantified by proton magnetic resonance spectroscopy in PMd and SMA in both injured (ipsilesional) and un-injured (contralesional) hemispheres. Correlations between metabolites were also calculated. Finally, relationships between metabolite concentrations and arm motor impairment (total and proximal Fugl-Meyer Upper Extremity, FMUE, scores) were analyzed. Compared to controls, stroke survivors showed significantly higher ipsilesional PMd myo-inositol and lower SMA N-acetylaspartate. Significantly lower metabolite correlations were found between ipsilesional and contralesional SMA. Ipsilesional N-acetylaspartate was significantly related to proximal FMUE scores. This study provides evidence of abnormalities in metabolites, specific to neuronal and glial compartments, across spared non-primary motor areas. Ipsilesional alterations were related to proximal arm motor impairment. Our results suggest the involvement of these areas in post-stroke reorganization.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalBrain Research
Volume1463
DOIs
StatePublished - Jun 29 2012
Externally publishedYes

Fingerprint

Motor Cortex
Neuroglia
Stroke
Arm
Inositol
Survivors
Paresis
Glutamine
Upper Extremity
Glutamic Acid
N-acetylaspartate

Keywords

  • H-MRS
  • Neuronal and glial compartments
  • Non-primary motor areas
  • Subcortical stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Cirstea, C. M., Nudo, R. J., Craciunas, S. C., Popescu, E. A., Choi, I. Y., Lee, P., ... Brooks, W. M. (2012). Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. Brain Research, 1463, 75-84. https://doi.org/10.1016/j.brainres.2012.04.052

Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. / Cirstea, Carmen M.; Nudo, Randolph J.; Craciunas, Sorin C.; Popescu, Elena A.; Choi, In Young; Lee, Phil; Yeh, Hung Wen; Savage, Cary R; Brooks, William M.

In: Brain Research, Vol. 1463, 29.06.2012, p. 75-84.

Research output: Contribution to journalArticle

Cirstea, CM, Nudo, RJ, Craciunas, SC, Popescu, EA, Choi, IY, Lee, P, Yeh, HW, Savage, CR & Brooks, WM 2012, 'Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke', Brain Research, vol. 1463, pp. 75-84. https://doi.org/10.1016/j.brainres.2012.04.052
Cirstea CM, Nudo RJ, Craciunas SC, Popescu EA, Choi IY, Lee P et al. Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. Brain Research. 2012 Jun 29;1463:75-84. https://doi.org/10.1016/j.brainres.2012.04.052
Cirstea, Carmen M. ; Nudo, Randolph J. ; Craciunas, Sorin C. ; Popescu, Elena A. ; Choi, In Young ; Lee, Phil ; Yeh, Hung Wen ; Savage, Cary R ; Brooks, William M. / Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke. In: Brain Research. 2012 ; Vol. 1463. pp. 75-84.
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abstract = "Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent with their involvement in post-stroke reorganization. Specifically, we expected that neuronal and glial compartments would be altered in radiologically normal-appearing, i.e., spared, PMd and SMA in patients with arm paresis. Twenty survivors of a single ischemic subcortical stroke and 16 age-matched healthy controls were included. At more than six months after stroke, metabolites related to neuronal and glial compartments: N-acetylaspartate, myo-inositol, and glutamate/glutamine, were quantified by proton magnetic resonance spectroscopy in PMd and SMA in both injured (ipsilesional) and un-injured (contralesional) hemispheres. Correlations between metabolites were also calculated. Finally, relationships between metabolite concentrations and arm motor impairment (total and proximal Fugl-Meyer Upper Extremity, FMUE, scores) were analyzed. Compared to controls, stroke survivors showed significantly higher ipsilesional PMd myo-inositol and lower SMA N-acetylaspartate. Significantly lower metabolite correlations were found between ipsilesional and contralesional SMA. Ipsilesional N-acetylaspartate was significantly related to proximal FMUE scores. This study provides evidence of abnormalities in metabolites, specific to neuronal and glial compartments, across spared non-primary motor areas. Ipsilesional alterations were related to proximal arm motor impairment. Our results suggest the involvement of these areas in post-stroke reorganization.",
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