Abstract

Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical-basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the recording of oscillatory activity during movement planning, execution, and termination phases. Each of these phases was independently examined using beamforming to distinguish the brain areas and movement phases, where pathological oscillations exist during motor control. Patients with PD exhibited significantly diminished beta desynchronization compared with controls prior to and during movement, which paralleled reduced alpha desynchronization. This study is the first to systematically investigate neural oscillatory responses in PD during distinct stages of motor control (e.g. planning, execution, and termination) and indicates that these patients have significant difficulty suppressing cortical beta synchronization during movement planning, which may contribute to their diminished movement capacities.

Original languageEnglish (US)
Pages (from-to)2669-2678
Number of pages10
JournalCerebral Cortex
Volume24
Issue number10
DOIs
StatePublished - Jan 1 2014

Fingerprint

Dyskinesias
Parkinson Disease
Cortical Synchronization
Magnetoencephalography
Subthalamic Nucleus
Deep Brain Stimulation
Basal Ganglia
Scalp
Posture
Gait
Neurodegenerative Diseases
Electroencephalography
Research Design
Brain
Population

Keywords

  • Cortex
  • MEG
  • Magnetoencephalography
  • Motor control
  • Oscillations

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Neuromagnetic evidence of abnormal movement-related beta desynchronization in Parkinson's disease. / Heinrichs-Graham, Elizabeth C; Wilson, Tony W; Santamaria, Pamela M.; Heithoff, Sheila K.; Torres-Russotto, Diego; Hutter-Saunders, Jessica A L; Estes, Katherine A.; Meza, Jane L; Mosley, R Lee; Gendelman, Howard Eliot.

In: Cerebral Cortex, Vol. 24, No. 10, 01.01.2014, p. 2669-2678.

Research output: Contribution to journalArticle

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