Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR

T. R. Phillips, O. Prospero-Garcia, D. W. Wheeler, P. C. Wagaman, D. L. Lerner, H. S. Fox, L. R. Whalen, F. E. Bloom, J. H. Elder, S. J. Henriksen

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-FIV-PPR (a dUTPase mutant of the FIV-PPR clone) infected; or an age-matched control group. In both infected groups, the general clinical signs of infection included lymphadenopathy, oral ulcerations, rough hair coat, and conjuntivitis. Specific neurological changes in the FIV-PPR infected cats included hind limb paresis; delayed righting and pupillary reflexes; behavioral changes; delayed visual and auditory evoked potentials; decreased spinal and peripheral nerve conduction velocities; and marked alterations in sleep patterns. Most of these changes were also observed in the DU-FIV-PPR infected cats. However, these cats tended to have a slightly less severe disease. In this study, we have demonstrated that an infectious molecular clone of FIV closely parallels the disease course of wild type FIV-infected cats. By using a knockout gene mutant of this clone, we were able to demonstrate that the dUTPase gene is not essential for neuropathogenesis. Further use of the FIV-PPR clone should prove useful in determining the essential viral elements that are important in the neuropathogenesis of lentiviral infections.

Original languageEnglish (US)
Pages (from-to)388-396
Number of pages9
JournalJournal of neurovirology
Volume2
Issue number6
DOIs
StatePublished - Dec 1996

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Feline Immunodeficiency Virus
Neurologic Manifestations
Clone Cells
Cats
Pupillary Reflex
Righting Reflex
Specific Pathogen-Free Organisms
Spinal Nerves
Auditory Evoked Potentials
Lentivirus
Gene Knockout Techniques
Visual Evoked Potentials
Neural Conduction
Paresis
Infection
Peripheral Nerves
Hair
HIV Infections
Sleep
Research Design

Keywords

  • Electrophysiology
  • FIV
  • HIV
  • Lentivirus
  • Neurologic disease
  • dUTPase

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Cite this

Phillips, T. R., Prospero-Garcia, O., Wheeler, D. W., Wagaman, P. C., Lerner, D. L., Fox, H. S., ... Henriksen, S. J. (1996). Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR. Journal of neurovirology, 2(6), 388-396. https://doi.org/10.3109/13550289609146904

Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR. / Phillips, T. R.; Prospero-Garcia, O.; Wheeler, D. W.; Wagaman, P. C.; Lerner, D. L.; Fox, H. S.; Whalen, L. R.; Bloom, F. E.; Elder, J. H.; Henriksen, S. J.

In: Journal of neurovirology, Vol. 2, No. 6, 12.1996, p. 388-396.

Research output: Contribution to journalArticle

Phillips, TR, Prospero-Garcia, O, Wheeler, DW, Wagaman, PC, Lerner, DL, Fox, HS, Whalen, LR, Bloom, FE, Elder, JH & Henriksen, SJ 1996, 'Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR', Journal of neurovirology, vol. 2, no. 6, pp. 388-396. https://doi.org/10.3109/13550289609146904
Phillips, T. R. ; Prospero-Garcia, O. ; Wheeler, D. W. ; Wagaman, P. C. ; Lerner, D. L. ; Fox, H. S. ; Whalen, L. R. ; Bloom, F. E. ; Elder, J. H. ; Henriksen, S. J. / Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR. In: Journal of neurovirology. 1996 ; Vol. 2, No. 6. pp. 388-396.
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