Neurologic complications after high-dose chemotherapy and autologous bone marrow transplantation for hodgkin’s disease

Sandra Snider, Rifaat Bashir, Philip Jay Bierman

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We analyzed 168 consecutive patients with Hodgkinx0027;s disease who were treated at the University of Nebraska Medical Center between 1985 and 1990 with high-dose chemotherapy followed by autologous bone marrow transplantation (BMT) or peripheral stem-cell transplantation (PSCT), and describe their neurologic complications. All these patients had relapsed or had failed to achieve a remission with initial chemotherapy. Early complications, defined as those occurring during the first 6 weeks following the transplantation, occurred in 65 patients (39%) and included encephalopathy, seizures, psychiatric symptoms, and cerebral hemorrhage; these were mild and reversible in 47 and fatal in 18 patients. The major cause of these early neurologic complications was pulmonary failure. Late neurologic complications, defined as those occurring 6 weeks after the BMT or PSCT was performed, occurred in 21% of patients and included encephalopathy, peripheral neuropathy, cerebral hemorrhage, and spinal cord compression. Serious nervous system complications following autologous BMT or PSCT for Hodgkinx0027;s disease are less frequent than those following allogeneic BMT and are usually a result of injury to other organ systems.

Original languageEnglish (US)
Pages (from-to)681-684
Number of pages4
JournalNeurology
Volume44
Issue number4
StatePublished - Apr 1994

Fingerprint

Autologous Transplantation
Bone Marrow Transplantation
Hodgkin Disease
Nervous System
Peripheral Blood Stem Cell Transplantation
Drug Therapy
Cerebral Hemorrhage
Brain Diseases
Spinal Cord Compression
Homologous Transplantation
Peripheral Nervous System Diseases
Psychiatry
Seizures
Transplantation
Lung
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Neurologic complications after high-dose chemotherapy and autologous bone marrow transplantation for hodgkin’s disease. / Snider, Sandra; Bashir, Rifaat; Bierman, Philip Jay.

In: Neurology, Vol. 44, No. 4, 04.1994, p. 681-684.

Research output: Contribution to journalArticle

@article{94e89e8d9fc74edf988ea12814ad912b,
title = "Neurologic complications after high-dose chemotherapy and autologous bone marrow transplantation for hodgkin’s disease",
abstract = "We analyzed 168 consecutive patients with Hodgkinx0027;s disease who were treated at the University of Nebraska Medical Center between 1985 and 1990 with high-dose chemotherapy followed by autologous bone marrow transplantation (BMT) or peripheral stem-cell transplantation (PSCT), and describe their neurologic complications. All these patients had relapsed or had failed to achieve a remission with initial chemotherapy. Early complications, defined as those occurring during the first 6 weeks following the transplantation, occurred in 65 patients (39{\%}) and included encephalopathy, seizures, psychiatric symptoms, and cerebral hemorrhage; these were mild and reversible in 47 and fatal in 18 patients. The major cause of these early neurologic complications was pulmonary failure. Late neurologic complications, defined as those occurring 6 weeks after the BMT or PSCT was performed, occurred in 21{\%} of patients and included encephalopathy, peripheral neuropathy, cerebral hemorrhage, and spinal cord compression. Serious nervous system complications following autologous BMT or PSCT for Hodgkinx0027;s disease are less frequent than those following allogeneic BMT and are usually a result of injury to other organ systems.",
author = "Sandra Snider and Rifaat Bashir and Bierman, {Philip Jay}",
year = "1994",
month = "4",
language = "English (US)",
volume = "44",
pages = "681--684",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Neurologic complications after high-dose chemotherapy and autologous bone marrow transplantation for hodgkin’s disease

AU - Snider, Sandra

AU - Bashir, Rifaat

AU - Bierman, Philip Jay

PY - 1994/4

Y1 - 1994/4

N2 - We analyzed 168 consecutive patients with Hodgkinx0027;s disease who were treated at the University of Nebraska Medical Center between 1985 and 1990 with high-dose chemotherapy followed by autologous bone marrow transplantation (BMT) or peripheral stem-cell transplantation (PSCT), and describe their neurologic complications. All these patients had relapsed or had failed to achieve a remission with initial chemotherapy. Early complications, defined as those occurring during the first 6 weeks following the transplantation, occurred in 65 patients (39%) and included encephalopathy, seizures, psychiatric symptoms, and cerebral hemorrhage; these were mild and reversible in 47 and fatal in 18 patients. The major cause of these early neurologic complications was pulmonary failure. Late neurologic complications, defined as those occurring 6 weeks after the BMT or PSCT was performed, occurred in 21% of patients and included encephalopathy, peripheral neuropathy, cerebral hemorrhage, and spinal cord compression. Serious nervous system complications following autologous BMT or PSCT for Hodgkinx0027;s disease are less frequent than those following allogeneic BMT and are usually a result of injury to other organ systems.

AB - We analyzed 168 consecutive patients with Hodgkinx0027;s disease who were treated at the University of Nebraska Medical Center between 1985 and 1990 with high-dose chemotherapy followed by autologous bone marrow transplantation (BMT) or peripheral stem-cell transplantation (PSCT), and describe their neurologic complications. All these patients had relapsed or had failed to achieve a remission with initial chemotherapy. Early complications, defined as those occurring during the first 6 weeks following the transplantation, occurred in 65 patients (39%) and included encephalopathy, seizures, psychiatric symptoms, and cerebral hemorrhage; these were mild and reversible in 47 and fatal in 18 patients. The major cause of these early neurologic complications was pulmonary failure. Late neurologic complications, defined as those occurring 6 weeks after the BMT or PSCT was performed, occurred in 21% of patients and included encephalopathy, peripheral neuropathy, cerebral hemorrhage, and spinal cord compression. Serious nervous system complications following autologous BMT or PSCT for Hodgkinx0027;s disease are less frequent than those following allogeneic BMT and are usually a result of injury to other organ systems.

UR - http://www.scopus.com/inward/record.url?scp=0028303056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028303056&partnerID=8YFLogxK

M3 - Article

C2 - 8164825

AN - SCOPUS:0028303056

VL - 44

SP - 681

EP - 684

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -