Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology

Tony W Wilson, Elizabeth C Heinrichs-Graham, Amy L. Proskovec, Timothy J. McDermott

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Magnetoencephalography (MEG) is a noninvasive, silent, and totally passive neurophysiological imaging method with excellent temporal resolution (∼1 ms) and good spatial precision (∼3–5 mm). In a typical experiment, MEG data are acquired as healthy controls or patients with neurologic or psychiatric disorders perform a specific cognitive task, or receive sensory stimulation. The resulting data are generally analyzed using standard electrophysiological methods, coupled with advanced image reconstruction algorithms. To date, the total number of MEG instruments and associated users is significantly smaller than comparable human neuroimaging techniques, although this is likely to change in the near future with advances in the technology. Despite this small base, MEG research has made a significant impact on several areas of translational neuroscience, largely through its unique capacity to quantify the oscillatory dynamics of activated brain circuits in humans. This review focuses on the clinical areas where MEG imaging has arguably had the greatest impact in regard to the identification of aberrant neural dynamics at the regional and network level, monitoring of disease progression, determining how efficacious pharmacologic and behavioral interventions modulate neural systems, and the development of neural markers of disease. Specifically, this review covers recent advances in understanding the abnormal neural oscillatory dynamics that underlie Parkinson's disease, autism spectrum disorders, human immunodeficiency virus (HIV)-associated neurocognitive disorders, cerebral palsy, attention-deficit hyperactivity disorder, cognitive aging, and post-traumatic stress disorder. MEG imaging has had a major impact on how clinical neuroscientists understand the brain basis of these disorders, and its translational influence is rapidly expanding with new discoveries and applications emerging continuously.

Original languageEnglish (US)
Pages (from-to)17-36
Number of pages20
JournalTranslational Research
Volume175
DOIs
StatePublished - Sep 1 2016

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Magnetoencephalography
Neuroimaging
Brain
Imaging techniques
Computer-Assisted Image Processing
Brain Diseases
Cerebral Palsy
Attention Deficit Disorder with Hyperactivity
Post-Traumatic Stress Disorders
Neurosciences
Image reconstruction
Viruses
Nervous System
Parkinson Disease
Psychiatry
Disease Progression
Aging of materials
HIV
Technology
Networks (circuits)

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

Cite this

Neuroimaging with magnetoencephalography : A dynamic view of brain pathophysiology. / Wilson, Tony W; Heinrichs-Graham, Elizabeth C; Proskovec, Amy L.; McDermott, Timothy J.

In: Translational Research, Vol. 175, 01.09.2016, p. 17-36.

Research output: Contribution to journalReview article

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