Neurogenic actions of atypical antipsychotic drugs and therapeutic implications

Samuel Sathyanesan, Ronald S. Duman

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

Brain imaging and postmortem studies have reported a reduction in the volume of discrete brain regions, as well as cellular abnormalities in schizophrenic patients. In addition, basic research studies have demonstrated effects of antipsychotic drugs on cell morphology and number. Of particular interest is adult neurogenesis, which has been linked to cognitive and memory improvements, and is also associated with the behavioural actions of antidepressants. While the action of antidepressant treatment is restricted mainly to the hippocampus, long-term administration of antipsychotics is reported to increase neurogenesis in the subventricular zone (SVZ), as well as the subgranular zone (SGZ) of the hippocampus. In addition, antipsychotic drugs increase the proliferation of nonneuronal cell types in the prefrontal cortex and could thereby influence the function of this brain region. Typical and atypical antipsychotic drugs differentially regulate neurogenesis in the SVZ and SGZ. Although the therapeutic relevance remains speculative, the results are consistent with the hypothesis that the actions of antipsychotic agents could be mediated, in part, by increased proliferation of neuronal as well as glial cells. Additional animal studies and postmortem analyses are required to further test this possibility and to investigate the relevance of this work in the pathophysiology and treatment of schizophrenia.

Original languageEnglish (US)
Pages (from-to)715-725
Number of pages11
JournalCNS Drugs
Volume21
Issue number9
DOIs
StatePublished - Aug 27 2007

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Antipsychotic Agents
Neurogenesis
Lateral Ventricles
Antidepressive Agents
Hippocampus
Therapeutics
Brain
Prefrontal Cortex
Neuroimaging
Neuroglia
Schizophrenia
Cell Count
Cell Proliferation
Research

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Pharmacology

Cite this

Neurogenic actions of atypical antipsychotic drugs and therapeutic implications. / Sathyanesan, Samuel; Duman, Ronald S.

In: CNS Drugs, Vol. 21, No. 9, 27.08.2007, p. 715-725.

Research output: Contribution to journalReview article

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