Neurodevelopmental outcomes in children with Fontan repair of functional single ventricle

Karen Uzark, Alan Lincoln, John J. Lamberti, Richard D. Mainwaring, Robert L. Spicer, John W. Moore

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Objectives. The purpose of this study was to assess the neurodevelopmental status of children after Fontan repair of functional single ventricle and to examine the relationship between cognitive function and selected patient characteristics. Study Design. Neurodevelopmental tests including the Stanford-Binet Intelligence (IQ) scale and the Developmental Test of Visual Motor Integration (VMI) were administered to 32 children (26 months to 16 years of age) with complex single ventricle. The mean and distribution of IQ and VMI scores were compared with population norms. The relationship between test scores and patient characteristics was examined utilizing analysis of variance and correlational methods. Results. The majority of children had intellectual function within the normal range (mean, 97.5 ± 12.1). Below average VMI scores were found in 21.4% of children. There were no significant correlations between intellectual function or visual motor integration ability and preoperative oxygen saturation or age at Fontan. Children who had deep hypothermic circulatory arrest during a prior Norwood procedure tended to have a lower IQ score. Conclusions. Intellectual development in children with Fontan repair of complex heart defects is essentially within the normal range. Visual motor integration deficits may be more prevalent in these children. In our population, the duration and degree of preoperative hypoxemia had no apparent effect on cognitive function.

Original languageEnglish (US)
Pages (from-to)630-633
Number of pages4
JournalPediatrics
Volume101
Issue number4 I
DOIs
StatePublished - Apr 1 1998

Fingerprint

Cognition
Stanford-Binet Test
Reference Values
Norwood Procedures
Deep Hypothermia Induced Circulatory Arrest
Aptitude
Child Development
Intelligence
Population
Analysis of Variance
Oxygen
Hypoxia

Keywords

  • Fontan repair
  • Neurodevelopmental outcome
  • Single ventricle

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Uzark, K., Lincoln, A., Lamberti, J. J., Mainwaring, R. D., Spicer, R. L., & Moore, J. W. (1998). Neurodevelopmental outcomes in children with Fontan repair of functional single ventricle. Pediatrics, 101(4 I), 630-633. https://doi.org/10.1542/peds.101.4.630

Neurodevelopmental outcomes in children with Fontan repair of functional single ventricle. / Uzark, Karen; Lincoln, Alan; Lamberti, John J.; Mainwaring, Richard D.; Spicer, Robert L.; Moore, John W.

In: Pediatrics, Vol. 101, No. 4 I, 01.04.1998, p. 630-633.

Research output: Contribution to journalArticle

Uzark, K, Lincoln, A, Lamberti, JJ, Mainwaring, RD, Spicer, RL & Moore, JW 1998, 'Neurodevelopmental outcomes in children with Fontan repair of functional single ventricle', Pediatrics, vol. 101, no. 4 I, pp. 630-633. https://doi.org/10.1542/peds.101.4.630
Uzark, Karen ; Lincoln, Alan ; Lamberti, John J. ; Mainwaring, Richard D. ; Spicer, Robert L. ; Moore, John W. / Neurodevelopmental outcomes in children with Fontan repair of functional single ventricle. In: Pediatrics. 1998 ; Vol. 101, No. 4 I. pp. 630-633.
@article{b65a3d49a350463fb583326ce90d52f4,
title = "Neurodevelopmental outcomes in children with Fontan repair of functional single ventricle",
abstract = "Objectives. The purpose of this study was to assess the neurodevelopmental status of children after Fontan repair of functional single ventricle and to examine the relationship between cognitive function and selected patient characteristics. Study Design. Neurodevelopmental tests including the Stanford-Binet Intelligence (IQ) scale and the Developmental Test of Visual Motor Integration (VMI) were administered to 32 children (26 months to 16 years of age) with complex single ventricle. The mean and distribution of IQ and VMI scores were compared with population norms. The relationship between test scores and patient characteristics was examined utilizing analysis of variance and correlational methods. Results. The majority of children had intellectual function within the normal range (mean, 97.5 ± 12.1). Below average VMI scores were found in 21.4{\%} of children. There were no significant correlations between intellectual function or visual motor integration ability and preoperative oxygen saturation or age at Fontan. Children who had deep hypothermic circulatory arrest during a prior Norwood procedure tended to have a lower IQ score. Conclusions. Intellectual development in children with Fontan repair of complex heart defects is essentially within the normal range. Visual motor integration deficits may be more prevalent in these children. In our population, the duration and degree of preoperative hypoxemia had no apparent effect on cognitive function.",
keywords = "Fontan repair, Neurodevelopmental outcome, Single ventricle",
author = "Karen Uzark and Alan Lincoln and Lamberti, {John J.} and Mainwaring, {Richard D.} and Spicer, {Robert L.} and Moore, {John W.}",
year = "1998",
month = "4",
day = "1",
doi = "10.1542/peds.101.4.630",
language = "English (US)",
volume = "101",
pages = "630--633",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "4 I",

}

TY - JOUR

T1 - Neurodevelopmental outcomes in children with Fontan repair of functional single ventricle

AU - Uzark, Karen

AU - Lincoln, Alan

AU - Lamberti, John J.

AU - Mainwaring, Richard D.

AU - Spicer, Robert L.

AU - Moore, John W.

PY - 1998/4/1

Y1 - 1998/4/1

N2 - Objectives. The purpose of this study was to assess the neurodevelopmental status of children after Fontan repair of functional single ventricle and to examine the relationship between cognitive function and selected patient characteristics. Study Design. Neurodevelopmental tests including the Stanford-Binet Intelligence (IQ) scale and the Developmental Test of Visual Motor Integration (VMI) were administered to 32 children (26 months to 16 years of age) with complex single ventricle. The mean and distribution of IQ and VMI scores were compared with population norms. The relationship between test scores and patient characteristics was examined utilizing analysis of variance and correlational methods. Results. The majority of children had intellectual function within the normal range (mean, 97.5 ± 12.1). Below average VMI scores were found in 21.4% of children. There were no significant correlations between intellectual function or visual motor integration ability and preoperative oxygen saturation or age at Fontan. Children who had deep hypothermic circulatory arrest during a prior Norwood procedure tended to have a lower IQ score. Conclusions. Intellectual development in children with Fontan repair of complex heart defects is essentially within the normal range. Visual motor integration deficits may be more prevalent in these children. In our population, the duration and degree of preoperative hypoxemia had no apparent effect on cognitive function.

AB - Objectives. The purpose of this study was to assess the neurodevelopmental status of children after Fontan repair of functional single ventricle and to examine the relationship between cognitive function and selected patient characteristics. Study Design. Neurodevelopmental tests including the Stanford-Binet Intelligence (IQ) scale and the Developmental Test of Visual Motor Integration (VMI) were administered to 32 children (26 months to 16 years of age) with complex single ventricle. The mean and distribution of IQ and VMI scores were compared with population norms. The relationship between test scores and patient characteristics was examined utilizing analysis of variance and correlational methods. Results. The majority of children had intellectual function within the normal range (mean, 97.5 ± 12.1). Below average VMI scores were found in 21.4% of children. There were no significant correlations between intellectual function or visual motor integration ability and preoperative oxygen saturation or age at Fontan. Children who had deep hypothermic circulatory arrest during a prior Norwood procedure tended to have a lower IQ score. Conclusions. Intellectual development in children with Fontan repair of complex heart defects is essentially within the normal range. Visual motor integration deficits may be more prevalent in these children. In our population, the duration and degree of preoperative hypoxemia had no apparent effect on cognitive function.

KW - Fontan repair

KW - Neurodevelopmental outcome

KW - Single ventricle

UR - http://www.scopus.com/inward/record.url?scp=0031952795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031952795&partnerID=8YFLogxK

U2 - 10.1542/peds.101.4.630

DO - 10.1542/peds.101.4.630

M3 - Article

C2 - 9521946

AN - SCOPUS:0031952795

VL - 101

SP - 630

EP - 633

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4 I

ER -