Neurobiological candidate endophenotypes of social anxiety disorder

Janna Marie Bas-Hoogendam, Jennifer U. Blackford, Annette B. Brühl, Karina Blair, Nic J.A. van der Wee, P. Michiel Westenberg

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Social anxiety disorder (SAD) is a disabling psychiatric disorder with a complex pathogenesis. Studies indicate a genetic component in the development of SAD, but the search for genetic mechanisms underlying this vulnerability is complicated. A focus on endophenotypes instead of the disorder itself may provide a fruitful path forward. Endophenotypes are measurable characteristics related to complex psychiatric disorders and reflective of genetically-based disease mechanisms, and could shed light on the ways by which genes contribute to the development of SAD. We review evidence for candidate MRI endophenotypes of SAD and discuss the extent to which they meet the criteria for an endophenotype, focussing on the amygdala, the medial prefrontal cortex, whole-brain functional connectivity and structural-anatomical changes. Strongest evidence is present for the primary endophenotype criterion of association between the candidate endophenotypes and SAD, while the other criteria, involving trait-stability, heritability and co-segregation of the endophenotype with the disorder within families, warrant further investigation. We highlight the potential of neuroimaging endophenotypes and stress the need for family studies into SAD endophenotypes.

Original languageEnglish (US)
Pages (from-to)362-378
Number of pages17
JournalNeuroscience and Biobehavioral Reviews
Volume71
DOIs
StatePublished - Dec 1 2016

Fingerprint

Endophenotypes
Psychiatry
Social Phobia
Amygdala
Prefrontal Cortex
Neuroimaging

Keywords

  • Amygdala
  • Connectivity
  • Endophenotypes
  • Genetic vulnerability
  • Medial prefrontal cortex
  • Neuroimaging
  • Social anxiety disorder
  • Uncinate fasciculus

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Bas-Hoogendam, J. M., Blackford, J. U., Brühl, A. B., Blair, K., van der Wee, N. J. A., & Westenberg, P. M. (2016). Neurobiological candidate endophenotypes of social anxiety disorder. Neuroscience and Biobehavioral Reviews, 71, 362-378. https://doi.org/10.1016/j.neubiorev.2016.08.040

Neurobiological candidate endophenotypes of social anxiety disorder. / Bas-Hoogendam, Janna Marie; Blackford, Jennifer U.; Brühl, Annette B.; Blair, Karina; van der Wee, Nic J.A.; Westenberg, P. Michiel.

In: Neuroscience and Biobehavioral Reviews, Vol. 71, 01.12.2016, p. 362-378.

Research output: Contribution to journalReview article

Bas-Hoogendam, JM, Blackford, JU, Brühl, AB, Blair, K, van der Wee, NJA & Westenberg, PM 2016, 'Neurobiological candidate endophenotypes of social anxiety disorder', Neuroscience and Biobehavioral Reviews, vol. 71, pp. 362-378. https://doi.org/10.1016/j.neubiorev.2016.08.040
Bas-Hoogendam, Janna Marie ; Blackford, Jennifer U. ; Brühl, Annette B. ; Blair, Karina ; van der Wee, Nic J.A. ; Westenberg, P. Michiel. / Neurobiological candidate endophenotypes of social anxiety disorder. In: Neuroscience and Biobehavioral Reviews. 2016 ; Vol. 71. pp. 362-378.
@article{d1a0a63b75cc4c8f98ed0a64507cf259,
title = "Neurobiological candidate endophenotypes of social anxiety disorder",
abstract = "Social anxiety disorder (SAD) is a disabling psychiatric disorder with a complex pathogenesis. Studies indicate a genetic component in the development of SAD, but the search for genetic mechanisms underlying this vulnerability is complicated. A focus on endophenotypes instead of the disorder itself may provide a fruitful path forward. Endophenotypes are measurable characteristics related to complex psychiatric disorders and reflective of genetically-based disease mechanisms, and could shed light on the ways by which genes contribute to the development of SAD. We review evidence for candidate MRI endophenotypes of SAD and discuss the extent to which they meet the criteria for an endophenotype, focussing on the amygdala, the medial prefrontal cortex, whole-brain functional connectivity and structural-anatomical changes. Strongest evidence is present for the primary endophenotype criterion of association between the candidate endophenotypes and SAD, while the other criteria, involving trait-stability, heritability and co-segregation of the endophenotype with the disorder within families, warrant further investigation. We highlight the potential of neuroimaging endophenotypes and stress the need for family studies into SAD endophenotypes.",
keywords = "Amygdala, Connectivity, Endophenotypes, Genetic vulnerability, Medial prefrontal cortex, Neuroimaging, Social anxiety disorder, Uncinate fasciculus",
author = "Bas-Hoogendam, {Janna Marie} and Blackford, {Jennifer U.} and Br{\"u}hl, {Annette B.} and Karina Blair and {van der Wee}, {Nic J.A.} and Westenberg, {P. Michiel}",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.neubiorev.2016.08.040",
language = "English (US)",
volume = "71",
pages = "362--378",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Neurobiological candidate endophenotypes of social anxiety disorder

AU - Bas-Hoogendam, Janna Marie

AU - Blackford, Jennifer U.

AU - Brühl, Annette B.

AU - Blair, Karina

AU - van der Wee, Nic J.A.

AU - Westenberg, P. Michiel

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Social anxiety disorder (SAD) is a disabling psychiatric disorder with a complex pathogenesis. Studies indicate a genetic component in the development of SAD, but the search for genetic mechanisms underlying this vulnerability is complicated. A focus on endophenotypes instead of the disorder itself may provide a fruitful path forward. Endophenotypes are measurable characteristics related to complex psychiatric disorders and reflective of genetically-based disease mechanisms, and could shed light on the ways by which genes contribute to the development of SAD. We review evidence for candidate MRI endophenotypes of SAD and discuss the extent to which they meet the criteria for an endophenotype, focussing on the amygdala, the medial prefrontal cortex, whole-brain functional connectivity and structural-anatomical changes. Strongest evidence is present for the primary endophenotype criterion of association between the candidate endophenotypes and SAD, while the other criteria, involving trait-stability, heritability and co-segregation of the endophenotype with the disorder within families, warrant further investigation. We highlight the potential of neuroimaging endophenotypes and stress the need for family studies into SAD endophenotypes.

AB - Social anxiety disorder (SAD) is a disabling psychiatric disorder with a complex pathogenesis. Studies indicate a genetic component in the development of SAD, but the search for genetic mechanisms underlying this vulnerability is complicated. A focus on endophenotypes instead of the disorder itself may provide a fruitful path forward. Endophenotypes are measurable characteristics related to complex psychiatric disorders and reflective of genetically-based disease mechanisms, and could shed light on the ways by which genes contribute to the development of SAD. We review evidence for candidate MRI endophenotypes of SAD and discuss the extent to which they meet the criteria for an endophenotype, focussing on the amygdala, the medial prefrontal cortex, whole-brain functional connectivity and structural-anatomical changes. Strongest evidence is present for the primary endophenotype criterion of association between the candidate endophenotypes and SAD, while the other criteria, involving trait-stability, heritability and co-segregation of the endophenotype with the disorder within families, warrant further investigation. We highlight the potential of neuroimaging endophenotypes and stress the need for family studies into SAD endophenotypes.

KW - Amygdala

KW - Connectivity

KW - Endophenotypes

KW - Genetic vulnerability

KW - Medial prefrontal cortex

KW - Neuroimaging

KW - Social anxiety disorder

KW - Uncinate fasciculus

UR - http://www.scopus.com/inward/record.url?scp=84988710963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988710963&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2016.08.040

DO - 10.1016/j.neubiorev.2016.08.040

M3 - Review article

VL - 71

SP - 362

EP - 378

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -