Neuro-cognitive system dysfunction and symptom sets

A review of fMRI studies in youth with conduct problems

Robert James Blair, K. Veroude, J. K. Buitelaar

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

In this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent and its functional role/the symptom sets consequent on its dysfunction remain underspecified. However, dysfunctions in the other four neuro-cognitive systems are associated with symptom sets seen in individuals with conduct problems.

Original languageEnglish (US)
Pages (from-to)69-90
Number of pages22
JournalNeuroscience and Biobehavioral Reviews
Volume91
DOIs
StatePublished - Aug 1 2018

Fingerprint

Attention Deficit and Disruptive Behavior Disorders
Conduct Disorder
Neurobehavioral Manifestations
Decision Making
Magnetic Resonance Imaging
Reinforcement (Psychology)
Cognitive Dysfunction
Inhibition (Psychology)

Keywords

  • Aggression
  • Callous unemotional traits
  • Conduct disorder
  • Decision-making
  • Empathy

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Neuro-cognitive system dysfunction and symptom sets : A review of fMRI studies in youth with conduct problems. / Blair, Robert James; Veroude, K.; Buitelaar, J. K.

In: Neuroscience and Biobehavioral Reviews, Vol. 91, 01.08.2018, p. 69-90.

Research output: Contribution to journalReview article

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