Neural stem cells in the mammalian eye

Types and regulation

Iqbal Ahmad, Ani V. Das, Jackson James, Sumitra Bhattacharya, Xing Zhao

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

Neural Stem Cells
Stem Cells
Epithelium
Adult Stem Cells
Neuroglia
Cell Biology
Retina
Neurons
Brain
Population

Keywords

  • Ciliary epithelium
  • Hedgehog
  • Notch
  • Retina
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Neural stem cells in the mammalian eye : Types and regulation. / Ahmad, Iqbal; Das, Ani V.; James, Jackson; Bhattacharya, Sumitra; Zhao, Xing.

In: Seminars in Cell and Developmental Biology, Vol. 15, No. 1, 01.01.2004, p. 53-62.

Research output: Contribution to journalArticle

Ahmad, Iqbal ; Das, Ani V. ; James, Jackson ; Bhattacharya, Sumitra ; Zhao, Xing. / Neural stem cells in the mammalian eye : Types and regulation. In: Seminars in Cell and Developmental Biology. 2004 ; Vol. 15, No. 1. pp. 53-62.
@article{685d3744d6d14c6f912ede6d9ba5017a,
title = "Neural stem cells in the mammalian eye: Types and regulation",
abstract = "Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.",
keywords = "Ciliary epithelium, Hedgehog, Notch, Retina, Wnt",
author = "Iqbal Ahmad and Das, {Ani V.} and Jackson James and Sumitra Bhattacharya and Xing Zhao",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.semcdb.2003.09.003",
language = "English (US)",
volume = "15",
pages = "53--62",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Neural stem cells in the mammalian eye

T2 - Types and regulation

AU - Ahmad, Iqbal

AU - Das, Ani V.

AU - James, Jackson

AU - Bhattacharya, Sumitra

AU - Zhao, Xing

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.

AB - Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.

KW - Ciliary epithelium

KW - Hedgehog

KW - Notch

KW - Retina

KW - Wnt

UR - http://www.scopus.com/inward/record.url?scp=0842281542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842281542&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2003.09.003

DO - 10.1016/j.semcdb.2003.09.003

M3 - Article

VL - 15

SP - 53

EP - 62

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 1

ER -