Neural responses to visual food stimuli after a normal vs. higher protein breakfast in breakfast-skipping teens: A pilot fmri study

Heather J. Leidy, Rebecca J. Lepping, Cary R. Savage, Corey T. Harris

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

This functional magnetic resonance imaging (fMRI) pilot study identified whether breakfast consumption would alter the neural activity in brain regions associated with food motivation and reward in overweight breakfast skipping (BS) adolescent girls and examined whether increased protein at breakfast would lead to additional alterations. Ten girls (Age: 15±1 years; BMI percentile 93 1%; BS 5 1×/week) completed 3 testing days. Following the BS day, the participants were provided with, in randomized order, normal protein (NP; 18±1g protein) or higher protein (HP; 50±1g protein) breakfast meals to consume at home for 6 days. On day 7 of each pattern, the participants came to the laboratory to consume their respective breakfast followed by appetite questionnaires and an fMRI brain scan to identify brain activation responses to viewing food vs. nonfood images prior to lunch. Breakfast consumption led to enduring (i.e., 3-h post breakfast) reductions in neural activation in the hippocampus, amygdala, cingulate, and parahippocampus vs. BS. HP led to enduring reductions in insula and middle prefrontal cortex activation vs. NP. Hippocampal, amygdala, cingulate, and insular activations were correlated with appetite and inversely correlated with satiety. In summary, the addition of breakfast led to alterations in brain activation in regions previously associated with food motivation and reward with additional alterations following the higher-protein breakfast. These data suggest that increased dietary protein at breakfast might be a beneficial strategy to reduce reward-driven eating behavior in overweight teen girls. Due to the small sample size, caution is warranted when interpreting these preliminary findings.

Original languageEnglish (US)
Pages (from-to)2019-2025
Number of pages7
JournalObesity
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2011

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Breakfast
Food
Proteins
Reward
Brain
Appetite
Amygdala
Motivation
Magnetic Resonance Imaging
Lunch
Dietary Proteins
Feeding Behavior
Prefrontal Cortex
Sample Size
Meals
Hippocampus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Neural responses to visual food stimuli after a normal vs. higher protein breakfast in breakfast-skipping teens : A pilot fmri study. / Leidy, Heather J.; Lepping, Rebecca J.; Savage, Cary R.; Harris, Corey T.

In: Obesity, Vol. 19, No. 10, 01.10.2011, p. 2019-2025.

Research output: Contribution to journalArticle

Leidy, Heather J. ; Lepping, Rebecca J. ; Savage, Cary R. ; Harris, Corey T. / Neural responses to visual food stimuli after a normal vs. higher protein breakfast in breakfast-skipping teens : A pilot fmri study. In: Obesity. 2011 ; Vol. 19, No. 10. pp. 2019-2025.
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